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Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.
Bakeer N, James J, Roy S, Wansapura J, Shanmukhappa SK, Lorenz JN, Osinska H, Backer K, Huby AC, Shrestha A, Niss O, Fleck R, Quinn CT, Taylor MD, Purevjav E, Aronow BJ, Towbin JA, Malik P. Bakeer N, et al. Among authors: malik p. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5182-91. doi: 10.1073/pnas.1600311113. Epub 2016 Aug 8. Proc Natl Acad Sci U S A. 2016. PMID: 27503873 Free PMC article.
Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia.
Quinn CT, Niss O, Dong M, Pfeiffer A, Korpik J, Reynaud M, Bonar H, Kalfa TA, Smart LR, Malik P, Ware RE, Vinks AA, McGann PT. Quinn CT, et al. Among authors: malik p. Br J Haematol. 2021 Aug;194(3):617-625. doi: 10.1111/bjh.17663. Epub 2021 Jul 5. Br J Haematol. 2021. PMID: 34227124 Free PMC article. Clinical Trial.
812 results