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Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.
Gallagher FA, Kettunen MI, Hu DE, Jensen PR, Zandt RI, Karlsson M, Gisselsson A, Nelson SK, Witney TH, Bohndiek SE, Hansson G, Peitersen T, Lerche MH, Brindle KM. Gallagher FA, et al. Among authors: gisselsson a. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19801-6. doi: 10.1073/pnas.0911447106. Epub 2009 Nov 10. Proc Natl Acad Sci U S A. 2009. PMID: 19903889 Free PMC article.