Wigglesworth MJ - Search Results

1

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D. Miller PS, et al. Among authors: wigglesworth mj. Biochem Biophys Res Commun. 2010 Jan 1;391(1):437-42. doi: 10.1016/j.bbrc.2009.11.076. Epub 2009 Nov 13. Biochem Biophys Res Commun. 2010. PMID: 19914210 Free PMC article.

2

A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.

Weaver RE, Wigglesworth MJ, Donnelly D. Weaver RE, et al. Among authors: wigglesworth mj. Peptides. 2014 Nov;61:83-7. doi: 10.1016/j.peptides.2014.09.004. Epub 2014 Sep 13. Peptides. 2014. PMID: 25218037

3

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH₂) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.

Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D. Weaver RE, et al. Among authors: wigglesworth mj. Biochem Pharmacol. 2017 Mar 1;127:71-81. doi: 10.1016/j.bcp.2016.12.013. Epub 2016 Dec 22. Biochem Pharmacol. 2017. PMID: 28012961 Free PMC article.

4

Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.

Mann R, Wigglesworth MJ, Donnelly D. Mann R, et al. Among authors: wigglesworth mj. Mol Pharmacol. 2008 Sep;74(3):605-13. doi: 10.1124/mol.108.048017. Epub 2008 Jun 6. Mol Pharmacol. 2008. PMID: 18539702

5

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

Routledge SJ, Simms J, Clark A, Yeung HY, Wigglesworth MJ, Dickerson IM, Kitchen P, Ladds G, Poyner DR. Routledge SJ, et al. Among authors: wigglesworth mj. Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183174. doi: 10.1016/j.bbamem.2019.183174. Epub 2019 Dec 27. Biochim Biophys Acta Biomembr. 2020. PMID: 31887275 Free PMC article.

6

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.

Clark AJ, Mullooly N, Safitri D, Harris M, de Vries T, MaassenVanDenBrink A, Poyner DR, Gianni D, Wigglesworth M, Ladds G. Clark AJ, et al. Commun Biol. 2021 Jun 23;4(1):776. doi: 10.1038/s42003-021-02293-w. Commun Biol. 2021. PMID: 34163006 Free PMC article.

7

The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.

Wroblowski B, Wigglesworth MJ, Szekeres PG, Smith GD, Rahman SS, Nicholson NH, Muir AI, Hall A, Heer JP, Garland SL, Coates WJ. Wroblowski B, et al. Among authors: wigglesworth mj. J Med Chem. 2009 Feb 12;52(3):818-25. doi: 10.1021/jm800962k. J Med Chem. 2009. PMID: 19146417

8

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.

Pearce A, Redfern-Nichols T, Harris M, Poyner DR, Wigglesworth M, Ladds G. Pearce A, et al. Front Physiol. 2022 Mar 29;13:840763. doi: 10.3389/fphys.2022.840763. eCollection 2022. Front Physiol. 2022. PMID: 35422711 Free PMC article.

9

Engineering a Model Cell for Rational Tuning of GPCR Signaling.

Shaw WM, Yamauchi H, Mead J, Gowers GF, Bell DJ, Öling D, Larsson N, Wigglesworth M, Ladds G, Ellis T. Shaw WM, et al. Cell. 2019 Apr 18;177(3):782-796.e27. doi: 10.1016/j.cell.2019.02.023. Epub 2019 Apr 4. Cell. 2019. PMID: 30955892 Free PMC article.

10

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ. Brown AJ, et al. Among authors: wigglesworth mj. J Biol Chem. 2003 Mar 28;278(13):11312-9. doi: 10.1074/jbc.M211609200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496283 Free article.

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