Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.
Wang D, Stewart AK, Zhuang L, Zhu Y, Wang Y, Shi C, Keating A, Slutsky A, Zhang H, Wen XY.
Wang D, et al. Among authors: zhang h.
FASEB J. 2010 Mar;24(3):947-56. doi: 10.1096/fj.09-140806. Epub 2009 Nov 18.
FASEB J. 2010.
PMID: 19923443
We further demonstrate that the Hacs1(-/-) B cells had increased global tyrosine phosphorylation, including tyrosine kinases Lyn and Akt. Both T-helper type 1 (T(h)1) and T-helper type 2 (T(h)2) humoral responses were enhanced in Hacs1(-/-) mice. ...K., Zhuang, L., …
We further demonstrate that the Hacs1(-/-) B cells had increased global tyrosine phosphorylation, including tyrosine kinases Lyn and Akt. Bo …