Frost CE - Search Results

1

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.

Wang L, Zhang D, Raghavan N, Yao M, Ma L, Frost CE, Maxwell BD, Chen SY, He K, Goosen TC, Humphreys WG, Grossman SJ. Wang L, et al. Among authors: frost ce. Drug Metab Dispos. 2010 Mar;38(3):448-58. doi: 10.1124/dmd.109.029694. Epub 2009 Nov 25. Drug Metab Dispos. 2010. PMID: 19940026

2

Apixaban metabolism and pharmacokinetics after oral administration to humans.

Raghavan N, Frost CE, Yu Z, He K, Zhang H, Humphreys WG, Pinto D, Chen S, Bonacorsi S, Wong PC, Zhang D. Raghavan N, et al. Among authors: frost ce. Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832478

3

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

Zhang D, He K, Raghavan N, Wang L, Mitroka J, Maxwell BD, Knabb RM, Frost C, Schuster A, Hao F, Gu Z, Humphreys WG, Grossman SJ. Zhang D, et al. Drug Metab Dispos. 2009 Aug;37(8):1738-48. doi: 10.1124/dmd.108.025981. Epub 2009 May 6. Drug Metab Dispos. 2009. PMID: 19420130 Clinical Trial.

4

A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects.

Barrett YC, Wang J, Song Y, Pursley J, Wastall P, Wright R, Lacreta F, Frost C. Barrett YC, et al. Thromb Haemost. 2012 May;107(5):916-24. doi: 10.1160/TH11-09-0634. Epub 2012 Mar 8. Thromb Haemost. 2012. PMID: 22398784 Clinical Trial.

5

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG. Zhang D, et al. Among authors: frost ce. Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4. Drug Metab Dispos. 2013. PMID: 23382458

6

Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.

Zhang D, Frost CE, He K, Rodrigues AD, Wang X, Wang L, Goosen TC, Humphreys WG. Zhang D, et al. Among authors: frost ce. Drug Metab Dispos. 2013 Apr;41(4):906-15. doi: 10.1124/dmd.112.050575. Epub 2013 Feb 5. Drug Metab Dispos. 2013. PMID: 23386703

7

Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects.

Frost C, Nepal S, Wang J, Schuster A, Byon W, Boyd RA, Yu Z, Shenker A, Barrett YC, Mosqueda-Garcia R, Lacreta F. Frost C, et al. Br J Clin Pharmacol. 2013 Nov;76(5):776-86. doi: 10.1111/bcp.12106. Br J Clin Pharmacol. 2013. PMID: 23451769 Free PMC article. Clinical Trial.

8

Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects.

Upreti VV, Wang J, Barrett YC, Byon W, Boyd RA, Pursley J, LaCreta FP, Frost CE. Upreti VV, et al. Among authors: frost ce. Br J Clin Pharmacol. 2013 Dec;76(6):908-16. doi: 10.1111/bcp.12114. Br J Clin Pharmacol. 2013. PMID: 23488672 Free PMC article. Clinical Trial.

9

Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects.

Wang X, Mondal S, Wang J, Tirucherai G, Zhang D, Boyd RA, Frost C. Wang X, et al. Am J Cardiovasc Drugs. 2014 Apr;14(2):147-54. doi: 10.1007/s40256-013-0055-y. Am J Cardiovasc Drugs. 2014. PMID: 24277644 Free PMC article. Clinical Trial.

10

Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban.

Frost C, Shenker A, Gandhi MD, Pursley J, Barrett YC, Wang J, Zhang D, Byon W, Boyd RA, LaCreta F. Frost C, et al. Br J Clin Pharmacol. 2014 Oct;78(4):877-85. doi: 10.1111/bcp.12393. Br J Clin Pharmacol. 2014. PMID: 24697979 Free PMC article. Clinical Trial.

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