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A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Hartz RA, Ahuja VT, Zhuo X, Mattson RJ, Denhart DJ, Deskus JA, Vrudhula VM, Pan S, Ditta JL, Shu YZ, Grace JE, Lentz KA, Lelas S, Li YW, Molski TF, Krishnananthan S, Wong H, Qian-Cutrone J, Schartman R, Denton R, Lodge NJ, Zaczek R, Macor JE, Bronson JJ. Hartz RA, et al. Among authors: bronson jj. J Med Chem. 2009 Dec 10;52(23):7653-68. doi: 10.1021/jm900716v. J Med Chem. 2009. PMID: 19954247
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.
Andres CJ, Bronson JJ, D'Andrea SV, Deshpande MS, Falk PJ, Grant-Young KA, Harte WE, Ho HT, Misco PF, Robertson JG, Stock D, Sun Y, Walsh AW. Andres CJ, et al. Among authors: bronson jj. Bioorg Med Chem Lett. 2000 Apr 17;10(8):715-7. doi: 10.1016/s0960-894x(00)00073-1. Bioorg Med Chem Lett. 2000. PMID: 10782671
Biaryl diacid inhibitors of human s-PLA2 with anti-inflammatory activity.
Springer DM, Luh BY, Bronson JJ, McElhone KE, Mansuri MM, Gregor KR, Nettleton DO, Stanley PL, Tramposch KM. Springer DM, et al. Among authors: bronson jj. Bioorg Med Chem. 2000 May;8(5):1087-109. doi: 10.1016/s0968-0896(00)00047-x. Bioorg Med Chem. 2000. PMID: 10882020
Anti-MRSA cephems. Part 3: additional C-7 acid derivatives.
Springer DM, Luh BY, Goodrich JT, Bronson JJ. Springer DM, et al. Among authors: bronson jj. Bioorg Med Chem. 2003 Jan 17;11(2):281-91. doi: 10.1016/s0968-0896(02)00335-8. Bioorg Med Chem. 2003. PMID: 12470721
Cyclopentanone ring-cleaved pleuromutilin derivatives.
Springer DM, Bunker A, Luh BY, Sorenson ME, Goodrich JT, Bronson JJ, DenBleyker K, Dougherty TJ, Fung-Tomc J. Springer DM, et al. Among authors: bronson jj. Eur J Med Chem. 2007 Jan;42(1):109-13. doi: 10.1016/j.ejmech.2006.07.018. Epub 2006 Dec 6. Eur J Med Chem. 2007. PMID: 17156897
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
Parker MF, Barten DM, Bergstrom CP, Bronson JJ, Corsa JA, Deshpande MS, Felsenstein KM, Guss VL, Hansel SB, Johnson G, Keavy DJ, Lau WY, Mock J, Prasad CV, Polson CT, Sloan CP, Smith DW, Wallace OB, Wang HH, Williams A, Zheng M. Parker MF, et al. Among authors: bronson jj. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4432-6. doi: 10.1016/j.bmcl.2007.06.022. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17606371
88 results