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Page 1
From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors.
Lau CK, Black WC, Belley M, Chan C, Charleson S, Denis D, Gauthier JY, Gordon R, Guay D, Hamel P, Kargman S, Leblanc Y, Mancini J, Ouellet M, Percival D, Prasit P, Roy P, Skorey K, Tagari P, Vickers P, Wong E. Lau CK, et al. Among authors: black wc. Adv Exp Med Biol. 1997;407:73-8. Adv Exp Med Biol. 1997. PMID: 9321934 No abstract available.
Structure-based design of COX-2 selectivity into flurbiprofen.
Bayly CI, Black WC, Léger S, Ouimet N, Ouellet M, Percival MD. Bayly CI, et al. Among authors: black wc. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. doi: 10.1016/s0960-894x(98)00717-3. Bioorg Med Chem Lett. 1999. PMID: 10091674
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, Hughes G, Jolicoeur P, Leblanc Y, Nicoll-Griffith D, Ouimet N, Riendeau D, Visco D, Wang Z, Xu L, Prasit P. Black WC, et al. J Med Chem. 1999 Apr 8;42(7):1274-81. doi: 10.1021/jm980642l. J Med Chem. 1999. PMID: 10197970
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Li CS, Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Thérien M, Visco DM, Wong E, Xu L, Prasit P. Li CS, et al. Among authors: black wc. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3181-6. doi: 10.1016/s0960-894x(99)00559-4. Bioorg Med Chem Lett. 1999. PMID: 10576684
Nicotinyl aspartyl ketones as inhibitors of caspase-3.
Isabel E, Black WC, Bayly CI, Grimm EL, Janes MK, McKay DJ, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Thornberry NA, Vaillancourt JP, Xanthoudakis S, Zamboni R. Isabel E, et al. Among authors: black wc. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2137-40. doi: 10.1016/s0960-894x(03)00390-1. Bioorg Med Chem Lett. 2003. PMID: 12798321
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.
Black WC, Bayly CI, Davis DE, Desmarais S, Falgueyret JP, Léger S, Li CS, Massé F, McKay DJ, Palmer JT, Percival MD, Robichaud J, Tsou N, Zamboni R. Black WC, et al. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4741-4. doi: 10.1016/j.bmcl.2005.07.071. Bioorg Med Chem Lett. 2005. PMID: 16154747
415 results