Cheng KC - Search Results

1

P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.

Nair LG, Sannigrahi M, Bogen S, Pinto P, Chen KX, Prongay A, Tong X, Cheng KC, Girijavallabhan V, George Njoroge F. Nair LG, et al. Among authors: cheng kc. Bioorg Med Chem Lett. 2010 Jan 15;20(2):567-70. doi: 10.1016/j.bmcl.2009.11.094. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20004570

2

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors.

Li C, Nair L, Liu T, Li F, Pichardo J, Agrawal S, Chase R, Tong X, Uss AS, Bogen S, Njoroge FG, Morrison RA, Cheng KC. Li C, et al. Among authors: cheng kc. Biochem Pharmacol. 2008 Mar 1;75(5):1186-97. doi: 10.1016/j.bcp.2007.10.031. Epub 2007 Nov 7. Biochem Pharmacol. 2008. PMID: 18164692

3

The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor.

Chen KX, Vibulbhan B, Liu T, Broske L, Wang G, Li C, Njoroge FG, Uss AS, Cheng KC. Chen KX, et al. Among authors: cheng kc. Drug Metab Lett. 2009 Dec;3(4):290-5. doi: 10.2174/187231209790218091. Drug Metab Lett. 2009. PMID: 19995330

4

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans.

Li C, Liu T, Broske L, Brisson JM, Uss AS, Njoroge FG, Morrison RA, Cheng KC. Li C, et al. Among authors: cheng kc. Biochem Pharmacol. 2008 Dec 15;76(12):1757-64. doi: 10.1016/j.bcp.2008.09.005. Epub 2008 Sep 13. Biochem Pharmacol. 2008. PMID: 18835257

5

Current drug discovery strategies for treatment of hepatitis C virus infection.

Cheng KC, Gupta S, Wang H, Uss AS, Njoroge GF, Hughes E. Cheng KC, et al. J Pharm Pharmacol. 2011 Jul;63(7):883-92. doi: 10.1111/j.2042-7158.2011.01267.x. Epub 2011 May 19. J Pharm Pharmacol. 2011. PMID: 21635253 Review.

6

The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a thrombin receptor antagonist for development.

Hsieh Y, Cheng KC, Wang Y, Chackalamannil S, Xia Y, Korfmacher WA, White RE. Hsieh Y, et al. Among authors: cheng kc. Curr Pharm Des. 2009;15(19):2262-9. doi: 10.2174/138161209788682497. Curr Pharm Des. 2009. PMID: 19601827

7

Prediction of oral drug absorption in humans--from cultured cell lines and experimental animals.

Cheng KC, Li C, Uss AS. Cheng KC, et al. Expert Opin Drug Metab Toxicol. 2008 May;4(5):581-90. doi: 10.1517/17425255.4.5.581. Expert Opin Drug Metab Toxicol. 2008. PMID: 18484916 Review.

8

Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.

Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC. Xiao L, et al. Among authors: cheng kc. Biochem Pharmacol. 2011 Mar 1;81(5):669-79. doi: 10.1016/j.bcp.2010.12.003. Epub 2010 Dec 9. Biochem Pharmacol. 2011. PMID: 21145880

9

Development of a high-throughput in vitro assay using a novel Caco-2/rat hepatocyte system for the prediction of oral plasma area under the concentration versus time curve (AUC) in rats.

Cheng KC, Li C, Hsieh Y, Montgomery D, Liu T, White RE. Cheng KC, et al. J Pharmacol Toxicol Methods. 2006 May-Jun;53(3):215-8. doi: 10.1016/j.vascn.2005.08.002. Epub 2005 Sep 21. J Pharmacol Toxicol Methods. 2006. PMID: 16181794

10

Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction.

Chen J, Tran C, Xiao L, Palamanda J, Klapmuts T, Kumari P, Lin X, Wang EJ, Gu YZ, Humphries M, Uss AS, Cheng KC. Chen J, et al. Among authors: cheng kc. Drug Metab Lett. 2009 Jan;3(1):61-6. doi: 10.2174/187231209787176399. Drug Metab Lett. 2009. PMID: 19356119

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

775 results

Search Page

Filters