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Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.
Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL. Zhang M, et al. Among authors: rosen cj. J Biol Chem. 2002 Nov 15;277(46):44005-12. doi: 10.1074/jbc.M208265200. Epub 2002 Sep 4. J Biol Chem. 2002. PMID: 12215457 Free article.
Circulating levels of IGF-1 directly regulate bone growth and density.
Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Yakar S, et al. Among authors: rosen cj. J Clin Invest. 2002 Sep;110(6):771-81. doi: 10.1172/JCI15463. J Clin Invest. 2002. PMID: 12235108 Free PMC article.
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Yakar S, et al. Among authors: rosen cj. FASEB J. 2009 Mar;23(3):709-19. doi: 10.1096/fj.08-118976. Epub 2008 Oct 24. FASEB J. 2009. PMID: 18952711 Free PMC article.
637 results