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Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors.
Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Dutta R, et al. Among authors: edberg dd. Ann Neurol. 2013 May;73(5):637-45. doi: 10.1002/ana.23860. Epub 2013 Apr 17. Ann Neurol. 2013. PMID: 23595422 Free PMC article.
A mouse model for testing remyelinating therapies.
Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. Bai CB, et al. Exp Neurol. 2016 Sep;283(Pt A):330-40. doi: 10.1016/j.expneurol.2016.06.033. Epub 2016 Jul 3. Exp Neurol. 2016. PMID: 27384502 Free PMC article.