Chai SC - Search Results

1

Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.

Lu JP, Chai SC, Ye QZ. Lu JP, et al. Among authors: chai sc. J Med Chem. 2010 Feb 11;53(3):1329-37. doi: 10.1021/jm901624n. J Med Chem. 2010. PMID: 20038112 Free PMC article.

2

FE(II) is the native cofactor for Escherichia coli methionine aminopeptidase.

Chai SC, Wang WL, Ye QZ. Chai SC, et al. J Biol Chem. 2008 Oct 3;283(40):26879-85. doi: 10.1074/jbc.M804345200. Epub 2008 Jul 31. J Biol Chem. 2008. PMID: 18669631 Free PMC article.

3

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.

Wang WL, Chai SC, Huang M, He HZ, Hurley TD, Ye QZ. Wang WL, et al. Among authors: chai sc. J Med Chem. 2008 Oct 9;51(19):6110-20. doi: 10.1021/jm8005788. Epub 2008 Sep 12. J Med Chem. 2008. PMID: 18785729 Free PMC article.

4

Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase.

Wang WL, Chai SC, Ye QZ. Wang WL, et al. Among authors: chai sc. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1080-3. doi: 10.1016/j.bmcl.2009.01.011. Epub 2009 Jan 10. Bioorg Med Chem Lett. 2009. PMID: 19167218 Free PMC article.

5

Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme.

Chai SC, Lu JP, Ye QZ. Chai SC, et al. Anal Biochem. 2009 Dec 15;395(2):263-4. doi: 10.1016/j.ab.2009.07.054. Epub 2009 Aug 25. Anal Biochem. 2009. PMID: 19712663 Free PMC article.

6

Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase.

Chai SC, Ye QZ. Chai SC, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6862-4. doi: 10.1016/j.bmcl.2009.10.082. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19889537 Free PMC article.

7

Analysis of the stoichiometric metal activation of methionine aminopeptidase.

Chai SC, Ye QZ. Chai SC, et al. BMC Biochem. 2009 Dec 17;10:32. doi: 10.1186/1471-2091-10-32. BMC Biochem. 2009. PMID: 20017927 Free PMC article.

8

A cell-based assay that targets methionine aminopeptidase in a physiologically relevant environment.

Chai SC, Ye QZ. Chai SC, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2129-32. doi: 10.1016/j.bmcl.2010.02.052. Epub 2010 Feb 16. Bioorg Med Chem Lett. 2010. PMID: 20207144 Free PMC article.

9

Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes.

Yuan H, Chai SC, Lam CK, Howard Xu H, Ye QZ. Yuan H, et al. Among authors: chai sc. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3395-8. doi: 10.1016/j.bmcl.2011.03.116. Epub 2011 Apr 7. Bioorg Med Chem Lett. 2011. PMID: 21524572 Free PMC article.

10

Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase.

Chai SC, Wang WL, Ding DR, Ye QZ. Chai SC, et al. Eur J Med Chem. 2011 Aug;46(8):3537-40. doi: 10.1016/j.ejmech.2011.04.056. Epub 2011 May 5. Eur J Med Chem. 2011. PMID: 21575996 Free PMC article.

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