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Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Sanchez Canedo C, et al. Among authors: bayascas jr. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E761-9. doi: 10.1152/ajpendo.00421.2009. Epub 2010 Jan 5. Am J Physiol Endocrinol Metab. 2010. PMID: 20051528 Free article.
Regulation of Akt/PKB Ser473 phosphorylation.
Bayascas JR, Alessi DR. Bayascas JR, et al. Mol Cell. 2005 Apr 15;18(2):143-5. doi: 10.1016/j.molcel.2005.03.020. Mol Cell. 2005. PMID: 15837416 Free article.
LKB1-dependent signaling pathways.
Alessi DR, Sakamoto K, Bayascas JR. Alessi DR, et al. Among authors: bayascas jr. Annu Rev Biochem. 2006;75:137-63. doi: 10.1146/annurev.biochem.75.103004.142702. Annu Rev Biochem. 2006. PMID: 16756488 Review.
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. Bayascas JR, et al. Mol Cell Biol. 2008 May;28(10):3258-72. doi: 10.1128/MCB.02032-07. Epub 2008 Mar 17. Mol Cell Biol. 2008. PMID: 18347057 Free PMC article.
41 results