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Identification and characterization of the first small molecule inhibitor of MDMX.
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Reed D, et al. Among authors: schulman ba. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. J Biol Chem. 2010. PMID: 20080970 Free PMC article.
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA, Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J, Singh B, Harper JW, Schulman BA, Guy RK. Scott DC, et al. Among authors: schulman ba. Nat Chem Biol. 2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. Nat Chem Biol. 2017. PMID: 28581483 Free PMC article.
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. Hammill JT, et al. Among authors: schulman ba. J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26. J Med Chem. 2018. PMID: 29547693 Free PMC article.
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.
Richeson KV, Bodrug T, Sackton KL, Yamaguchi M, Paulo JA, Gygi SP, Schulman BA, Brown NG, King RW. Richeson KV, et al. Among authors: schulman ba. Nat Chem Biol. 2020 May;16(5):546-555. doi: 10.1038/s41589-020-0495-z. Epub 2020 Mar 9. Nat Chem Biol. 2020. PMID: 32152539 Free PMC article.
205 results