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Mdm2 and p53 are highly conserved from placozoans to man.
Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: cheok cf. Cell Cycle. 2010 Feb 1;9(3):540-7. doi: 10.4161/cc.9.3.10516. Cell Cycle. 2010. PMID: 20081368 Free article.
Reactivation of p53: from peptides to small molecules.
Brown CJ, Cheok CF, Verma CS, Lane DP. Brown CJ, et al. Among authors: cheok cf. Trends Pharmacol Sci. 2011 Jan;32(1):53-62. doi: 10.1016/j.tips.2010.11.004. Epub 2010 Dec 8. Trends Pharmacol Sci. 2011. PMID: 21145600 Review.
The Mdm2 and p53 genes are conserved in the Arachnids.
Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: cheok cf. Cell Cycle. 2010 Feb 15;9(4):748-54. doi: 10.4161/cc.9.4.10616. Epub 2010 Feb 12. Cell Cycle. 2010. PMID: 20160485 Free article.
p53-based cancer therapy.
Lane DP, Cheok CF, Lain S. Lane DP, et al. Among authors: cheok cf. Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a001222. doi: 10.1101/cshperspect.a001222. Epub 2010 May 12. Cold Spring Harb Perspect Biol. 2010. PMID: 20463003 Free PMC article. Review.
Translating p53 into the clinic.
Cheok CF, Verma CS, Baselga J, Lane DP. Cheok CF, et al. Nat Rev Clin Oncol. 2011 Jan;8(1):25-37. doi: 10.1038/nrclinonc.2010.174. Epub 2010 Oct 26. Nat Rev Clin Oncol. 2011. PMID: 20975744 Review.
New insights into p53 based therapy.
Lane DP, Brown CJ, Verma C, Cheok CF. Lane DP, et al. Among authors: cheok cf. Discov Med. 2011 Aug;12(63):107-17. Discov Med. 2011. PMID: 21878188 Free article. Review.
Exploiting the p53 Pathway for Therapy.
Cheok CF, Lane DP. Cheok CF, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026310. doi: 10.1101/cshperspect.a026310. Cold Spring Harb Perspect Med. 2017. PMID: 28193768 Free PMC article. Review.
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC. Kong LR, et al. Among authors: cheok cf. Nat Commun. 2020 Apr 29;11(1):2086. doi: 10.1038/s41467-020-15608-y. Nat Commun. 2020. PMID: 32350249 Free PMC article.
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