Abagyan R - Search Results

1

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: abagyan r. J Biol Chem. 2010 Mar 26;285(13):9919-9931. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25. J Biol Chem. 2010. PMID: 20100828 Free PMC article.

2

Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors.

Cavasotto CN, Orry AJ, Abagyan RA. Cavasotto CN, et al. Proteins. 2003 May 15;51(3):423-33. doi: 10.1002/prot.10362. Proteins. 2003. PMID: 12696053

3

Efficient synthetic inhibitors of anthrax lethal factor.

Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M. Forino M, et al. Among authors: abagyan ra. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504. doi: 10.1073/pnas.0502733102. Epub 2005 Jun 27. Proc Natl Acad Sci U S A. 2005. PMID: 15983377 Free PMC article.

4

Structure-based development of target-specific compound libraries.

Orry AJ, Abagyan RA, Cavasotto CN. Orry AJ, et al. Drug Discov Today. 2006 Mar;11(5-6):261-6. doi: 10.1016/S1359-6446(05)03717-7. Drug Discov Today. 2006. PMID: 16580603 Review.

5

Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction.

Dong M, Ding XQ, Thomas SE, Gao F, Lam PC, Abagyan R, Miller LJ. Dong M, et al. Among authors: abagyan r. Biochemistry. 2007 Apr 17;46(15):4522-31. doi: 10.1021/bi0622468. Epub 2007 Mar 24. Biochemistry. 2007. PMID: 17381074 Free PMC article.

6

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: abagyan r. Mol Pharmacol. 2007 Aug;72(2):280-90. doi: 10.1124/mol.107.035402. Epub 2007 May 2. Mol Pharmacol. 2007. PMID: 17475809

7

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.

Bisson WH, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R. Bisson WH, et al. Among authors: abagyan r. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. doi: 10.1073/pnas.0609752104. Epub 2007 Jul 2. Proc Natl Acad Sci U S A. 2007. PMID: 17606915 Free PMC article.

8

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.

Harikumar KG, Lam PC, Dong M, Sexton PM, Abagyan R, Miller LJ. Harikumar KG, et al. Among authors: abagyan r. J Biol Chem. 2007 Nov 9;282(45):32834-43. doi: 10.1074/jbc.M704563200. Epub 2007 Sep 7. J Biol Chem. 2007. PMID: 17827151 Free article.

9

Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.

Chrencik JE, Brooun A, Recht MI, Nicola G, Davis LK, Abagyan R, Widmer H, Pasquale EB, Kuhn P. Chrencik JE, et al. Among authors: abagyan r. J Biol Chem. 2007 Dec 14;282(50):36505-13. doi: 10.1074/jbc.M706340200. Epub 2007 Sep 26. J Biol Chem. 2007. PMID: 17897949 Free PMC article.

10

Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

Cavasotto CN, Orry AJ, Murgolo NJ, Czarniecki MF, Kocsi SA, Hawes BE, O'Neill KA, Hine H, Burton MS, Voigt JH, Abagyan RA, Bayne ML, Monsma FJ Jr. Cavasotto CN, et al. J Med Chem. 2008 Feb 14;51(3):581-8. doi: 10.1021/jm070759m. Epub 2008 Jan 17. J Med Chem. 2008. PMID: 18198821

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