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New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P. Francotte P, et al. Among authors: gillotin f. J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t. J Med Chem. 2010. PMID: 20108934 Free article.
Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
de Tullio P, Servais AC, Fillet M, Gillotin F, Somers F, Chiap P, Lebrun P, Pirotte B. de Tullio P, et al. Among authors: gillotin f. J Med Chem. 2011 Dec 22;54(24):8353-61. doi: 10.1021/jm200786z. Epub 2011 Nov 29. J Med Chem. 2011. PMID: 22077416
Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Gillotin F, Chiap P, Frédérich M, Van Heugen JC, Francotte P, Lebrun P, Pirotte B, de Tullio P. Gillotin F, et al. Drug Metab Dispos. 2010 Feb;38(2):232-40. doi: 10.1124/dmd.109.028928. Epub 2009 Oct 29. Drug Metab Dispos. 2010. PMID: 19875500