Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.
Watkins PB, Wrighton SA, Schuetz EG, Maurel P, Guzelian PS.
Watkins PB, et al.
J Biol Chem. 1986 May 15;261(14):6264-71.
J Biol Chem. 1986.
PMID: 3486184
Free article.
A., Maurel, P., Schuetz, E. G., Watkins, P. B., Young, B., and Guzelian, P. S. (1985) Biochemistry 24, 2171-2178). To investigate the mechanism of induction of P-450p, we treated rats for 4 days with these agents and found that dexamethasone and …
A., Maurel, P., Schuetz, E. G., Watkins, P. B., Young, B., and Guzelian, P. S. (1985) Biochemistry 24, 2171-2178 …