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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.
Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, Zhang J, Ding P, Apatira A, Chua J, Brandt R, Pine P, Goff D, Singh R, Payan DG, Hitoshi Y. Holland SJ, et al. Cancer Res. 2010 Feb 15;70(4):1544-54. doi: 10.1158/0008-5472.CAN-09-2997. Epub 2010 Feb 9. Cancer Res. 2010. PMID: 20145120
Multiple roles for the receptor tyrosine kinase axl in tumor formation.
Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE, McLaughlin J, Swift SE, Pali ES, Yam G, Wong S, Lasaga J, Shen MR, Yu S, Xu W, Hitoshi Y, Bogenberger J, Nör JE, Payan DG, Lorens JB. Holland SJ, et al. Cancer Res. 2005 Oct 15;65(20):9294-303. doi: 10.1158/0008-5472.CAN-05-0993. Cancer Res. 2005. PMID: 16230391
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. Among authors: holland sj. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma.
Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A. Hector A, et al. Among authors: holland sj. Cancer Biol Ther. 2010 Nov 15;10(10):1009-18. doi: 10.4161/cbt.10.10.13248. Epub 2010 Nov 15. Cancer Biol Ther. 2010. PMID: 20818175 Free PMC article.
The immunogenetics of sexual parasitism.
Swann JB, Holland SJ, Petersen M, Pietsch TW, Boehm T. Swann JB, et al. Among authors: holland sj. Science. 2020 Sep 25;369(6511):1608-1615. doi: 10.1126/science.aaz9445. Epub 2020 Jul 30. Science. 2020. PMID: 32732279
Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys.
Morimoto R, O'Meara CP, Holland SJ, Trancoso I, Souissi A, Schorpp M, Vassaux D, Iwanami N, Giorgetti OB, Evanno G, Boehm T. Morimoto R, et al. Among authors: holland sj. Sci Immunol. 2020 Mar 13;5(45):eaba0925. doi: 10.1126/sciimmunol.aba0925. Sci Immunol. 2020. PMID: 32169953
Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys.
Holland SJ, Berghuis LM, King JJ, Iyer LM, Sikora K, Fifield H, Peter S, Quinlan EM, Sugahara F, Shingate P, Trancoso I, Iwanami N, Temereva E, Strohmeier C, Kuratani S, Venkatesh B, Evanno G, Aravind L, Schorpp M, Larijani M, Boehm T. Holland SJ, et al. Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3211-E3220. doi: 10.1073/pnas.1720871115. Epub 2018 Mar 19. Proc Natl Acad Sci U S A. 2018. PMID: 29555777 Free PMC article.
47 results