Jaakola VP - Search Results

1

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

Jaakola VP, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC. Jaakola VP, et al. J Biol Chem. 2010 Apr 23;285(17):13032-44. doi: 10.1074/jbc.M109.096974. Epub 2010 Feb 10. J Biol Chem. 2010. PMID: 20147292 Free PMC article.

2

Designing facial amphiphiles for the stabilization of integral membrane proteins.

Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang G. Zhang Q, et al. Among authors: jaakola vp. Angew Chem Int Ed Engl. 2007;46(37):7023-5. doi: 10.1002/anie.200701556. Angew Chem Int Ed Engl. 2007. PMID: 17691085 No abstract available.

3

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression.

Hanson MA, Brooun A, Baker KA, Jaakola VP, Roth C, Chien EY, Alexandrov A, Velasquez J, Davis L, Griffith M, Moy K, Ganser-Pornillos BK, Hua Y, Kuhn P, Ellis S, Yeager M, Stevens RC. Hanson MA, et al. Among authors: jaakola vp. Protein Expr Purif. 2007 Nov;56(1):85-92. doi: 10.1016/j.pep.2007.06.003. Epub 2007 Jun 27. Protein Expr Purif. 2007. PMID: 17723307 Free PMC article.

4

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC. Hanson MA, et al. Among authors: jaakola vp. Structure. 2008 Jun;16(6):897-905. doi: 10.1016/j.str.2008.05.001. Structure. 2008. PMID: 18547522 Free PMC article.

5

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. Jaakola VP, et al. Science. 2008 Nov 21;322(5905):1211-7. doi: 10.1126/science.1164772. Epub 2008 Oct 2. Science. 2008. PMID: 18832607 Free PMC article.

6

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Katritch V, et al. Among authors: jaakola vp. J Med Chem. 2010 Feb 25;53(4):1799-809. doi: 10.1021/jm901647p. J Med Chem. 2010. PMID: 20095623 Free PMC article.

7

The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design.

Jaakola VP, Ijzerman AP. Jaakola VP, et al. Curr Opin Struct Biol. 2010 Aug;20(4):401-14. doi: 10.1016/j.sbi.2010.05.002. Epub 2010 Jun 9. Curr Opin Struct Biol. 2010. PMID: 20538452 Review.

8

The structure of the adenosine receptors: implications for drug discovery.

Lane JR, Jaakola VP, Ijzerman AP. Lane JR, et al. Among authors: jaakola vp. Adv Pharmacol. 2011;61:1-40. doi: 10.1016/B978-0-12-385526-8.00001-1. Adv Pharmacol. 2011. PMID: 21586354 Review.

9

Crystallogenesis of adenosine A(2A) receptor-T4 lysozyme fusion protein: a practical route for the structure.

Ashok Y, Nanekar RT, Jaakola VP. Ashok Y, et al. Among authors: jaakola vp. Methods Enzymol. 2013;520:175-98. doi: 10.1016/B978-0-12-391861-1.00008-3. Methods Enzymol. 2013. PMID: 23332700

10

Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner.

Piirainen H, Hellman M, Tossavainen H, Permi P, Kursula P, Jaakola VP. Piirainen H, et al. Among authors: jaakola vp. Biophys J. 2015 Feb 17;108(4):903-917. doi: 10.1016/j.bpj.2014.12.036. Biophys J. 2015. PMID: 25692595 Free PMC article.

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