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Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
Ambrose CM, Duyao MP, Barnes G, Bates GP, Lin CS, Srinidhi J, Baxendale S, Hummerich H, Lehrach H, Altherr M, Wasmuth J, Buckler A, Church D, Housman D, Berks M, Micklem G, Durbin R, Dodge A, Read A, Gusella J, MacDonald ME. Ambrose CM, et al. Somat Cell Mol Genet. 1994 Jan;20(1):27-38. doi: 10.1007/BF02257483. Somat Cell Mol Genet. 1994. PMID: 8197474
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM. Kawasaki H, et al. Among authors: housman de. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83. doi: 10.1073/pnas.95.22.13278. Proc Natl Acad Sci U S A. 1998. PMID: 9789079 Free PMC article.
A family of cAMP-binding proteins that directly activate Rap1.
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. Kawasaki H, et al. Among authors: housman de. Science. 1998 Dec 18;282(5397):2275-9. doi: 10.1126/science.282.5397.2275. Science. 1998. PMID: 9856955
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. Zhang X, et al. Among authors: housman de. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7. doi: 10.1073/pnas.0408936102. Epub 2005 Jan 10. Proc Natl Acad Sci U S A. 2005. PMID: 15642944 Free PMC article.
258 results