Lo DC - Search Results

1

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM. Crittenden JR, et al. Among authors: lo dc. Hum Mol Genet. 2010 May 1;19(9):1756-65. doi: 10.1093/hmg/ddq055. Epub 2010 Feb 10. Hum Mol Genet. 2010. PMID: 20147317 Free PMC article.

2

IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.

Khoshnan A, Sabbaugh A, Calamini B, Marinero SA, Dunn DE, Yoo JH, Ko J, Lo DC, Patterson PH. Khoshnan A, et al. Among authors: lo dc. Hum Mol Genet. 2017 Nov 1;26(21):4267-4277. doi: 10.1093/hmg/ddx315. Hum Mol Genet. 2017. PMID: 28973132 Free PMC article.

3

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay.

Reinhart PH, Kaltenbach LS, Essrich C, Dunn DE, Eudailey JA, DeMarco CT, Turmel GJ, Whaley JC, Wood A, Cho S, Lo DC. Reinhart PH, et al. Among authors: lo dc. Neurobiol Dis. 2011 Jul;43(1):248-56. doi: 10.1016/j.nbd.2011.03.017. Epub 2011 Mar 31. Neurobiol Dis. 2011. PMID: 21458569 Free PMC article.

4

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.

Baldo B, Paganetti P, Grueninger S, Marcellin D, Kaltenbach LS, Lo DC, Semmelroth M, Zivanovic A, Abramowski D, Smith D, Lotz GP, Bates GP, Weiss A. Baldo B, et al. Among authors: lo dc. Chem Biol. 2012 Feb 24;19(2):264-75. doi: 10.1016/j.chembiol.2011.12.020. Chem Biol. 2012. PMID: 22365609

5

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.

Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG 3rd, Lo DC, Stockwell BR. Kaplan A, et al. Among authors: lo dc. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52. doi: 10.1073/pnas.1500439112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848045 Free PMC article.

6

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E. Pirhaji L, et al. Among authors: lo dc. Nat Commun. 2017 Sep 20;8(1):623. doi: 10.1038/s41467-017-00353-6. Nat Commun. 2017. PMID: 28931805 Free PMC article.

7

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Skouta R, et al. Among authors: lo dc. J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14. J Am Chem Soc. 2014. PMID: 24592866 Free PMC article.

8

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.

Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH. Southwell AL, et al. Among authors: lo dc. J Neurosci. 2008 Sep 3;28(36):9013-20. doi: 10.1523/JNEUROSCI.2747-08.2008. J Neurosci. 2008. PMID: 18768695 Free PMC article.

9

In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.

Dunn DE, He DN, Yang P, Johansen M, Newman RA, Lo DC. Dunn DE, et al. Among authors: lo dc. J Neurochem. 2011 Nov;119(4):805-14. doi: 10.1111/j.1471-4159.2011.07439.x. Epub 2011 Sep 26. J Neurochem. 2011. PMID: 21950737 Free article.

10

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.

Southwell AL, Bugg CW, Kaltenbach LS, Dunn D, Butland S, Weiss A, Paganetti P, Lo DC, Patterson PH. Southwell AL, et al. Among authors: lo dc. PLoS One. 2011 Jan 31;6(1):e16676. doi: 10.1371/journal.pone.0016676. PLoS One. 2011. PMID: 21304966 Free PMC article.

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