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CLEC-2 activates Syk through dimerization.
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. Hughes CE, et al. Among authors: tomlinson mg. Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12. Blood. 2010. PMID: 20154219 Free PMC article.
Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.
Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP. Nicolson PLR, et al. Among authors: tomlinson mg. Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19. Haematologica. 2018. PMID: 30026342 Free PMC article.
Glycoprotein VI oligomerization in cell lines and platelets.
Berlanga O, Bori-Sanz T, James JR, Frampton J, Davis SJ, Tomlinson MG, Watson SP. Berlanga O, et al. Among authors: tomlinson mg. J Thromb Haemost. 2007 May;5(5):1026-1033. doi: 10.1111/j.1538-7836.2007.02449.x. Epub 2007 Mar 15. J Thromb Haemost. 2007. PMID: 17367493 Free PMC article.
Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.
Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG. Haining EJ, et al. Among authors: tomlinson mg. Platelets. 2017 Nov;28(7):629-642. doi: 10.1080/09537104.2016.1254175. Epub 2016 Dec 29. Platelets. 2017. PMID: 28032533 Free PMC article.
Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation.
Clark JC, Neagoe RAI, Zuidscherwoude M, Kavanagh DM, Slater A, Martin EM, Soave M, Stegner D, Nieswandt B, Poulter NS, Hummert J, Herten DP, Tomlinson MG, Hill SJ, Watson SP. Clark JC, et al. Among authors: tomlinson mg. Thromb Haemost. 2021 Nov;121(11):1435-1447. doi: 10.1055/a-1401-5014. Epub 2021 Apr 14. Thromb Haemost. 2021. PMID: 33638140
69 results