Yang G - Search Results

1

Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ. Oskarsson T, et al. Among authors: yang g. J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503. J Am Chem Soc. 2010. PMID: 20155906 Free PMC article.

2

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, Chiang A, Yang G, Ouerfelli O, Kris MG, Ladanyi M, Miller VA, Pao W. Balak MN, et al. Among authors: yang g. Clin Cancer Res. 2006 Nov 1;12(21):6494-501. doi: 10.1158/1078-0432.CCR-06-1570. Clin Cancer Res. 2006. PMID: 17085664

3

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. Antczak C, et al. Among authors: yang g. J Biomol Screen. 2007 Jun;12(4):521-35. doi: 10.1177/1087057107300463. Epub 2007 Apr 13. J Biomol Screen. 2007. PMID: 17435169 Free PMC article.

4

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM. Yang G, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):922-5. doi: 10.1016/j.bmcl.2008.11.117. Epub 2008 Dec 7. Bioorg Med Chem Lett. 2009. PMID: 19097779 Free PMC article.

5

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

Maretzky T, Yang G, Ouerfelli O, Overall CM, Worpenberg S, Hassiepen U, Eder J, Blobel CP. Maretzky T, et al. Among authors: yang g. Biochem J. 2009 Apr 28;420(1):105-13. doi: 10.1042/BJ20082127. Biochem J. 2009. PMID: 19207106

6

Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.

Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA. Escobar-Alvarez S, et al. Among authors: yang g. J Mol Biol. 2009 Apr 17;387(5):1211-28. doi: 10.1016/j.jmb.2009.02.032. Epub 2009 Feb 21. J Mol Biol. 2009. PMID: 19236878 Free PMC article.

7

Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

Nagorny P, Krauss I, Njardarson JT, Perez L, Gaul C, Yang G, Ouerfelli O, Danishefsky SJ. Nagorny P, et al. Among authors: yang g. Tetrahedron Lett. 2010 Jul 28;51(30):3873-3875. doi: 10.1016/j.tetlet.2010.05.056. Tetrahedron Lett. 2010. PMID: 20676392 Free PMC article.

8

Inhibition of human peptide deformylase disrupts mitochondrial function.

Escobar-Alvarez S, Gardner J, Sheth A, Manfredi G, Yang G, Ouerfelli O, Heaney ML, Scheinberg DA. Escobar-Alvarez S, et al. Among authors: yang g. Mol Cell Biol. 2010 Nov;30(21):5099-109. doi: 10.1128/MCB.00469-10. Epub 2010 Aug 30. Mol Cell Biol. 2010. PMID: 20805355 Free PMC article.

9

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Lecomte N, Njardarson JT, Nagorny P, Yang G, Downey R, Ouerfelli O, Moore MA, Danishefsky SJ. Lecomte N, et al. Among authors: yang g. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15074-8. doi: 10.1073/pnas.1015247108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2011. PMID: 21808037 Free PMC article.

10

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE. Somwar R, et al. Among authors: yang g. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. doi: 10.1073/pnas.1113554108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930909 Free PMC article.

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