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The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4.
Goruppi S, Kyriakis JM. Goruppi S, et al. Among authors: kyriakis jm. J Biol Chem. 2004 May 14;279(20):20950-8. doi: 10.1074/jbc.M312401200. Epub 2004 Mar 11. J Biol Chem. 2004. PMID: 15016802 Free article.
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U, Wang YM, Kyriakis J, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronovitz M, Tsichlis PN, Bhattacharya S, Force T, Kilter H. Shao Z, et al. Circ Res. 2006 Jan 6;98(1):111-8. doi: 10.1161/01.RES.0000197781.20524.b9. Epub 2005 Nov 23. Circ Res. 2006. PMID: 16306447
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