Helleday T - Search Results

1

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Petermann E, et al. Among authors: helleday t. Mol Cell. 2010 Feb 26;37(4):492-502. doi: 10.1016/j.molcel.2010.01.021. Mol Cell. 2010. PMID: 20188668 Free PMC article.

2

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.

Lundin C, Erixon K, Arnaudeau C, Schultz N, Jenssen D, Meuth M, Helleday T. Lundin C, et al. Among authors: helleday t. Mol Cell Biol. 2002 Aug;22(16):5869-78. doi: 10.1128/MCB.22.16.5869-5878.2002. Mol Cell Biol. 2002. PMID: 12138197 Free PMC article.

3

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells.

Lundin C, Schultz N, Arnaudeau C, Mohindra A, Hansen LT, Helleday T. Lundin C, et al. Among authors: helleday t. J Mol Biol. 2003 May 2;328(3):521-35. doi: 10.1016/s0022-2836(03)00313-9. J Mol Biol. 2003. PMID: 12706714

4

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.

Schultz N, Lopez E, Saleh-Gohari N, Helleday T. Schultz N, et al. Among authors: helleday t. Nucleic Acids Res. 2003 Sep 1;31(17):4959-64. doi: 10.1093/nar/gkg703. Nucleic Acids Res. 2003. PMID: 12930944 Free PMC article.

5

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.

Mohindra A, Bolderson E, Stone J, Wells M, Helleday T, Meuth M. Mohindra A, et al. Among authors: helleday t. Hum Mol Genet. 2004 Jan 15;13(2):203-12. doi: 10.1093/hmg/ddh022. Epub 2003 Nov 25. Hum Mol Genet. 2004. PMID: 14645207

6

p53 protects from replication-associated DNA double-strand breaks in mammalian cells.

Kumari A, Schultz N, Helleday T. Kumari A, et al. Among authors: helleday t. Oncogene. 2004 Mar 25;23(13):2324-9. doi: 10.1038/sj.onc.1207379. Oncogene. 2004. PMID: 14743204

7

ATM is required for the cellular response to thymidine induced replication fork stress.

Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M. Bolderson E, et al. Among authors: helleday t. Hum Mol Genet. 2004 Dec 1;13(23):2937-45. doi: 10.1093/hmg/ddh316. Epub 2004 Sep 30. Hum Mol Genet. 2004. PMID: 15459181

8

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T. Bryant HE, et al. Among authors: helleday t. Nature. 2005 Apr 14;434(7035):913-7. doi: 10.1038/nature03443. Nature. 2005. PMID: 15829966 Free article.

9

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.

Saleh-Gohari N, Bryant HE, Schultz N, Parker KM, Cassel TN, Helleday T. Saleh-Gohari N, et al. Among authors: helleday t. Mol Cell Biol. 2005 Aug;25(16):7158-69. doi: 10.1128/MCB.25.16.7158-7169.2005. Mol Cell Biol. 2005. PMID: 16055725 Free PMC article.

10

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.

Helleday T, Bryant HE, Schultz N. Helleday T, et al. Cell Cycle. 2005 Sep;4(9):1176-8. doi: 10.4161/cc.4.9.2031. Epub 2005 Sep 12. Cell Cycle. 2005. PMID: 16123586 Review.

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