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Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. Mali P, et al. Among authors: baylin sb. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402. Stem Cells. 2010. PMID: 20201064 Free PMC article.
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. Ohm JE, et al. Among authors: baylin sb. Nat Genet. 2007 Feb;39(2):237-42. doi: 10.1038/ng1972. Epub 2007 Jan 9. Nat Genet. 2007. PMID: 17211412 Free PMC article.
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB. Schuebel KE, et al. Among authors: baylin sb. PLoS Genet. 2007 Sep;3(9):1709-23. doi: 10.1371/journal.pgen.0030157. Epub 2007 Jul 31. PLoS Genet. 2007. PMID: 17892325 Free PMC article.
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.
Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Yi JM, et al. Among authors: baylin sb. Cancer Res. 2008 Oct 1;68(19):8094-103. doi: 10.1158/0008-5472.CAN-07-6208. Cancer Res. 2008. PMID: 18829568 Free PMC article.
584 results