Chenel M - Search Results

1

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

Perdaems N, Blasco H, Vinson C, Chenel M, Whalley S, Cazade F, Bouzom F. Perdaems N, et al. Among authors: chenel m. Clin Pharmacokinet. 2010 Apr;49(4):239-58. doi: 10.2165/11318130-000000000-00000. Clin Pharmacokinet. 2010. PMID: 20214408

2

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results.

Chenel M, Bouzom F, Cazade F, Ogungbenro K, Aarons L, Mentré F. Chenel M, et al. J Pharmacokinet Pharmacodyn. 2008 Dec;35(6):661-81. doi: 10.1007/s10928-008-9105-5. Epub 2009 Jan 7. J Pharmacokinet Pharmacodyn. 2008. PMID: 19130187 Free PMC article.

3

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes.

Chenel M, Bouzom F, Aarons L, Ogungbenro K. Chenel M, et al. J Pharmacokinet Pharmacodyn. 2008 Dec;35(6):635-59. doi: 10.1007/s10928-008-9104-6. Epub 2009 Jan 7. J Pharmacokinet Pharmacodyn. 2008. PMID: 19130188

4

Optimal sampling times for a drug and its metabolite using SIMCYP(®) simulations as prior information.

Dumont C, Mentré F, Gaynor C, Brendel K, Gesson C, Chenel M. Dumont C, et al. Among authors: chenel m. Clin Pharmacokinet. 2013 Jan;52(1):43-57. doi: 10.1007/s40262-012-0022-9. Clin Pharmacokinet. 2013. PMID: 23212609 Free article.

5

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.

Peigné S, Bouzom F, Brendel K, Gesson C, Fouliard S, Chenel M. Peigné S, et al. Among authors: chenel m. J Pharmacokinet Pharmacodyn. 2016 Feb;43(1):13-27. doi: 10.1007/s10928-015-9451-z. Epub 2015 Nov 12. J Pharmacokinet Pharmacodyn. 2016. PMID: 26563503

6

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.

Peigné S, Fouliard S, Decourcelle S, Chenel M. Peigné S, et al. Among authors: chenel m. J Pharmacokinet Pharmacodyn. 2016 Feb;43(1):29-43. doi: 10.1007/s10928-015-9452-y. Epub 2015 Nov 14. J Pharmacokinet Pharmacodyn. 2016. PMID: 26578442 Clinical Trial.

7

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling.

Ball K, Jamier T, Parmentier Y, Denizot C, Mallier A, Chenel M. Ball K, et al. Among authors: chenel m. Eur J Pharm Sci. 2017 Aug 30;106:122-132. doi: 10.1016/j.ejps.2017.05.055. Epub 2017 May 25. Eur J Pharm Sci. 2017. PMID: 28552429

8

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.

Pierrillas PB, Henin E, Ogier J, Kraus-Berthier L, Chenel M, Bouzom F, Tod M. Pierrillas PB, et al. Among authors: chenel m. J Pharmacol Exp Ther. 2018 Dec;367(3):414-424. doi: 10.1124/jpet.118.251694. Epub 2018 Sep 18. J Pharmacol Exp Ther. 2018. PMID: 30228112

9

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.

Pierrillas PB, Henin E, Ball K, Ogier J, Amiel M, Kraus-Berthier L, Chenel M, Bouzom F, Tod M. Pierrillas PB, et al. Among authors: chenel m. Drug Metab Dispos. 2019 Jun;47(6):648-656. doi: 10.1124/dmd.118.085605. Epub 2019 Apr 2. Drug Metab Dispos. 2019. PMID: 30940629

10

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.

Pierrillas PB, Henin E, Ogier J, Amiel M, Kraus-Berthier L, Chenel M, Bouzom F, Tod M. Pierrillas PB, et al. Among authors: chenel m. Invest New Drugs. 2020 Dec;38(6):1796-1806. doi: 10.1007/s10637-020-00953-y. Epub 2020 May 25. Invest New Drugs. 2020. PMID: 32451663

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