Lloyd DG - Search Results

1

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.

Barrett I, Carr M, O'Boyle N, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ. Barrett I, et al. Among authors: lloyd dg. J Enzyme Inhib Med Chem. 2010 Apr;25(2):180-94. doi: 10.3109/14756360903169659. J Enzyme Inhib Med Chem. 2010. PMID: 20222762 Free article.

2

Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor.

Lloyd DG, Hughes RB, Zisterer DM, Williams DC, Fattorusso C, Catalanotti B, Campiani G, Meegan MJ. Lloyd DG, et al. J Med Chem. 2004 Nov 4;47(23):5612-5. doi: 10.1021/jm0495834. J Med Chem. 2004. PMID: 15509159

3

Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists.

Lloyd DG, Smith HM, O'Sullivan T, Knox AS, Zisterer DM, Meegan MJ. Lloyd DG, et al. Med Chem. 2006 Mar;2(2):147-68. doi: 10.2174/157340606776056142. Med Chem. 2006. PMID: 16787364

4

Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.

Lloyd DG, Smith HM, O'Sullivan T, Zisterer DM, Meegan MJ. Lloyd DG, et al. Med Chem. 2005 Jul;1(4):335-53. doi: 10.2174/1573406054368666. Med Chem. 2005. PMID: 16789891

5

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

Smith HM, Knox AJ, Zisterer DM, Lloyd DG, Meegan MJ. Smith HM, et al. Among authors: lloyd dg. Med Chem. 2007 Mar;3(2):135-55. doi: 10.2174/157340607780059503. Med Chem. 2007. PMID: 17348852

6

Target specific virtual screening: optimization of an estrogen receptor screening platform.

Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG. Knox AJ, et al. Among authors: lloyd dg. J Med Chem. 2007 Nov 1;50(22):5301-10. doi: 10.1021/jm0700262. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918820

7

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

Meegan MJ, Barrett I, Zimmermann J, Knox AJ, Zisterer DM, Lloyd DG. Meegan MJ, et al. Among authors: lloyd dg. J Enzyme Inhib Med Chem. 2007 Oct;22(5):655-66. doi: 10.1080/14756360701503232. J Enzyme Inhib Med Chem. 2007. PMID: 18035834 Free article.

8

Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.

Meegan MJ, Carr M, Knox AJ, Zisterer DM, Lloyd DG. Meegan MJ, et al. Among authors: lloyd dg. J Enzyme Inhib Med Chem. 2008 Oct;23(5):668-85. doi: 10.1080/14756360802469127. J Enzyme Inhib Med Chem. 2008. PMID: 18821256 Free article.

9

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

Barrett I, Meegan MJ, Hughes RB, Carr M, Knox AJ, Artemenko N, Golfis G, Zisterer DM, Lloyd DG. Barrett I, et al. Among authors: lloyd dg. Bioorg Med Chem. 2008 Nov 1;16(21):9554-73. doi: 10.1016/j.bmc.2008.09.035. Epub 2008 Sep 16. Bioorg Med Chem. 2008. PMID: 18835176

10

Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.

Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG. Knox AJ, et al. Among authors: lloyd dg. J Med Chem. 2009 Apr 23;52(8):2177-80. doi: 10.1021/jm801569z. J Med Chem. 2009. PMID: 19331414

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