Wheeler VC - Search Results

1

A novel approach to investigate tissue-specific trinucleotide repeat instability.

Lee JM, Zhang J, Su AI, Walker JR, Wiltshire T, Kang K, Dragileva E, Gillis T, Lopez ET, Boily MJ, Cyr M, Kohane I, Gusella JF, MacDonald ME, Wheeler VC. Lee JM, et al. Among authors: wheeler vc. BMC Syst Biol. 2010 Mar 19;4:29. doi: 10.1186/1752-0509-4-29. BMC Syst Biol. 2010. PMID: 20302627 Free PMC article.

2

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.

Wheeler VC, Auerbach W, White JK, Srinidhi J, Auerbach A, Ryan A, Duyao MP, Vrbanac V, Weaver M, Gusella JF, Joyner AL, MacDonald ME. Wheeler VC, et al. Hum Mol Genet. 1999 Jan;8(1):115-22. doi: 10.1093/hmg/8.1.115. Hum Mol Genet. 1999. PMID: 9887339

3

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.

Wheeler VC, White JK, Gutekunst CA, Vrbanac V, Weaver M, Li XJ, Li SH, Yi H, Vonsattel JP, Gusella JF, Hersch S, Auerbach W, Joyner AL, MacDonald ME. Wheeler VC, et al. Hum Mol Genet. 2000 Mar 1;9(4):503-13. doi: 10.1093/hmg/9.4.503. Hum Mol Genet. 2000. PMID: 10699173

4

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.

Trettel F, Rigamonti D, Hilditch-Maguire P, Wheeler VC, Sharp AH, Persichetti F, Cattaneo E, MacDonald ME. Trettel F, et al. Among authors: wheeler vc. Hum Mol Genet. 2000 Nov 22;9(19):2799-809. doi: 10.1093/hmg/9.19.2799. Hum Mol Genet. 2000. PMID: 11092756

5

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.

Wheeler VC, Gutekunst CA, Vrbanac V, Lebel LA, Schilling G, Hersch S, Friedlander RM, Gusella JF, Vonsattel JP, Borchelt DR, MacDonald ME. Wheeler VC, et al. Hum Mol Genet. 2002 Mar 15;11(6):633-40. doi: 10.1093/hmg/11.6.633. Hum Mol Genet. 2002. PMID: 11912178

6

Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.

Fossale E, Wheeler VC, Vrbanac V, Lebel LA, Teed A, Mysore JS, Gusella JF, MacDonald ME, Persichetti F. Fossale E, et al. Among authors: wheeler vc. Hum Mol Genet. 2002 Sep 15;11(19):2233-41. doi: 10.1093/hmg/11.19.2233. Hum Mol Genet. 2002. PMID: 12217951

7

The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia.

Namura S, Hirt L, Wheeler VC, McGinnis KM, Hilditch-Maguire P, Moskowitz MA, MacDonald ME, Persichetti F. Namura S, et al. Among authors: wheeler vc. Neurobiol Dis. 2002 Oct;11(1):147-54. doi: 10.1006/nbdi.2002.0532. Neurobiol Dis. 2002. PMID: 12460554

8

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.

Wheeler VC, Lebel LA, Vrbanac V, Teed A, te Riele H, MacDonald ME. Wheeler VC, et al. Hum Mol Genet. 2003 Feb 1;12(3):273-81. doi: 10.1093/hmg/ddg056. Hum Mol Genet. 2003. PMID: 12554681

9

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.

Gines S, Seong IS, Fossale E, Ivanova E, Trettel F, Gusella JF, Wheeler VC, Persichetti F, MacDonald ME. Gines S, et al. Among authors: wheeler vc. Hum Mol Genet. 2003 Mar 1;12(5):497-508. doi: 10.1093/hmg/ddg046. Hum Mol Genet. 2003. PMID: 12588797

10

Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults.

Snider BJ, Moss JL, Revilla FJ, Lee CS, Wheeler VC, Macdonald ME, Choi DW. Snider BJ, et al. Among authors: wheeler vc. Neuroscience. 2003;120(3):617-25. doi: 10.1016/s0306-4522(03)00382-8. Neuroscience. 2003. PMID: 12895502

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