Alp NJ - Search Results

1

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Schmidt TS, McNeill E, Douglas G, Crabtree MJ, Hale AB, Khoo J, O'Neill CA, Cheng A, Channon KM, Alp NJ. Schmidt TS, et al. Among authors: alp nj. Clin Sci (Lond). 2010 May 6;119(3):131-42. doi: 10.1042/CS20090559. Clin Sci (Lond). 2010. PMID: 20337596

2

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.

Alp NJ, Channon KM. Alp NJ, et al. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):413-20. doi: 10.1161/01.ATV.0000110785.96039.f6. Epub 2003 Dec 4. Arterioscler Thromb Vasc Biol. 2004. PMID: 14656731 Review.

3

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.

Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM. Alp NJ, et al. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):445-50. doi: 10.1161/01.ATV.0000115637.48689.77. Epub 2004 Jan 5. Arterioscler Thromb Vasc Biol. 2004. PMID: 14707037

4

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, Wilkins MR, Channon KM. Khoo JP, et al. Among authors: alp nj. Circulation. 2005 Apr 26;111(16):2126-33. doi: 10.1161/01.CIR.0000162470.26840.89. Epub 2005 Apr 11. Circulation. 2005. PMID: 15824200

5

Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.

Schmidt TS, Alp NJ. Schmidt TS, et al. Among authors: alp nj. Clin Sci (Lond). 2007 Jul;113(2):47-63. doi: 10.1042/CS20070108. Clin Sci (Lond). 2007. PMID: 17555404 Review.

6

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

Ali ZA, Bursill CA, Douglas G, McNeill E, Papaspyridonos M, Tatham AL, Bendall JK, Akhtar AM, Alp NJ, Greaves DR, Channon KM. Ali ZA, et al. Among authors: alp nj. Circulation. 2008 Sep 30;118(14 Suppl):S71-7. doi: 10.1161/CIRCULATIONAHA.107.753558. Circulation. 2008. PMID: 18824773

7

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ. Crabtree MJ, et al. Among authors: alp nj. J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19011239 Free article.

8

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.

Tatham AL, Crabtree MJ, Warrick N, Cai S, Alp NJ, Channon KM. Tatham AL, et al. Among authors: alp nj. J Biol Chem. 2009 May 15;284(20):13660-13668. doi: 10.1074/jbc.M807959200. Epub 2009 Mar 13. J Biol Chem. 2009. PMID: 19286659 Free PMC article.

9

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.

Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM. Crabtree MJ, et al. Among authors: alp nj. J Biol Chem. 2009 Oct 9;284(41):28128-28136. doi: 10.1074/jbc.M109.041483. Epub 2009 Aug 7. J Biol Chem. 2009. PMID: 19666465 Free PMC article.

10

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM. Chuaiphichai S, et al. Among authors: alp nj. Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28. Hypertension. 2014. PMID: 24777984 Free PMC article.

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