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MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation.
Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M, Karsdal MA. Sondergaard BC, et al. Among authors: madsen sh. Osteoarthritis Cartilage. 2010 Mar;18(3):279-88. doi: 10.1016/j.joca.2009.11.005. Epub 2009 Nov 11. Osteoarthritis Cartilage. 2010. PMID: 19932675 Free article. Review.
Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.
Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, Klickstein L, Aggarwal P, Nemirovskiy O, Byrjalsen I, Qvist P, Bay-Jensen AC, Dam EB, Madsen SH, Christiansen C. Karsdal MA, et al. Among authors: madsen sh. Biomarkers. 2009 May;14(3):181-202. doi: 10.1080/13547500902777608. Biomarkers. 2009. PMID: 19399662 Review.
25 results