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Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.
Roell MK, Issafras H, Bauer RJ, Michelson KS, Mendoza N, Vanegas SI, Gross LM, Larsen PD, Bedinger DH, Bohmann DJ, Nonet GH, Liu N, Lee SR, Handa M, Kantak SS, Horwitz AH, Hunter JJ, Owyang AM, Mirza AM, Corbin JA, White ML. Roell MK, et al. Among authors: handa m. J Biol Chem. 2010 Jul 2;285(27):20607-14. doi: 10.1074/jbc.M110.115790. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410301 Free PMC article.
A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.
Bhaskar V, Goldfine ID, Bedinger DH, Lau A, Kuan HF, Gross LM, Handa M, Maddux BA, Watson SR, Zhu S, Narasimha AJ, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Tran C, Lee SR, Wong S, Wilcock D, White ML, Corbin JA. Bhaskar V, et al. Among authors: handa m. Diabetes. 2012 May;61(5):1263-71. doi: 10.2337/db11-1578. Epub 2012 Mar 8. Diabetes. 2012. PMID: 22403294 Free PMC article.
Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.
Corbin JA, Bhaskar V, Goldfine ID, Issafras H, Bedinger DH, Lau A, Michelson K, Gross LM, Maddux BA, Kuan HF, Tran C, Lao L, Handa M, Watson SR, Narasimha AJ, Zhu S, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Lee SR, Wong S, Wilcock D, Rubin P, White ML. Corbin JA, et al. Among authors: handa m. MAbs. 2014 Jan-Feb;6(1):262-72. doi: 10.4161/mabs.26871. MAbs. 2014. PMID: 24423625 Free PMC article.
Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.
Corbin JA, Bhaskar V, Goldfine ID, Bedinger DH, Lau A, Michelson K, Gross LM, Maddux BA, Kuan HF, Tran C, Lao L, Handa M, Watson SR, Narasimha AJ, Zhu S, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Lee SR, Wong S, Wilcock D, White ML. Corbin JA, et al. Among authors: handa m. PLoS One. 2014 Feb 12;9(2):e88684. doi: 10.1371/journal.pone.0088684. eCollection 2014. PLoS One. 2014. PMID: 24533136 Free PMC article.
523 results