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Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.
Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, Zuberek J, Darzynkiewicz E, Kuhn AN, Sahin U, Jemielity J. Strenkowska M, et al. Among authors: darzynkiewicz e. Nucleic Acids Res. 2016 Nov 16;44(20):9578-9590. doi: 10.1093/nar/gkw896. Epub 2016 Oct 7. Nucleic Acids Res. 2016. PMID: 27903882 Free PMC article.
Synthetic mRNAs with superior translation and stability properties.
Grudzien-Nogalska E, Kowalska J, Su W, Kuhn AN, Slepenkov SV, Darzynkiewicz E, Sahin U, Jemielity J, Rhoads RE. Grudzien-Nogalska E, et al. Among authors: darzynkiewicz e. Methods Mol Biol. 2013;969:55-72. doi: 10.1007/978-1-62703-260-5_4. Methods Mol Biol. 2013. PMID: 23296927 Review.
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.
Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J. Kowalska J, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22. Nucleic Acids Res. 2014. PMID: 25150148 Free PMC article.
The first examples of mRNA cap analogs bearing boranophosphate modification.
Kowalska J, Zuberek J, Darzynkiewicz ZM, Lukaszewicz M, Darzynkiewicz E, Jemielity J. Kowalska J, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Nucleic Acids Symp Ser (Oxf). 2008;(52):289-90. doi: 10.1093/nass/nrn146. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776367
169 results