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Page 1
Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection.
Yuan Z, McCauley R, Chen-Scarabelli C, Abounit K, Stephanou A, Barry SP, Knight R, Saravolatz SF, Saravolatz LD, Ulgen BO, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Scarabelli TM. Yuan Z, et al. Among authors: saravolatz ld, saravolatz l, saravolatz sf. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):1-7. doi: 10.1016/j.mce.2010.04.013. Epub 2010 Apr 21. Mol Cell Endocrinol. 2010. PMID: 20416357
Mechanisms of action and clinical implications of cardiac urocortin: a journey from the heart to the systemic circulation, with a stopover in the mitochondria.
Kuizon E, Pearce EG, Bailey SG, Chen-Scarabelli C, Yuan Z, Abounit K, McCauley RB, Saravolatz L, Faggian G, Mazzucco A, Townsend PA, Scarabelli TM. Kuizon E, et al. Int J Cardiol. 2009 Nov 12;137(3):189-94. doi: 10.1016/j.ijcard.2009.03.112. Epub 2009 Apr 29. Int J Cardiol. 2009. PMID: 19406492 Review.
The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway.
Chen-Scarabelli C, Saravolatz Ii L, McCaukey R, Scarabelli G, Di Rezze J, Mohanty B, Barry S, Latchman D, Georgiadis V, McCormick J, Saravolatz L, Knight R, Faggian G, Narula J, Stephanou A, Scarabelli TM. Chen-Scarabelli C, et al. JAKSTAT. 2013 Jul 1;2(3):e24812. doi: 10.4161/jkst.24812. Epub 2013 May 7. JAKSTAT. 2013. PMID: 24069562 Free PMC article.
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO.
Scarabelli TM, Stephanou A, Pasini E, Gitti G, Townsend P, Lawrence K, Chen-Scarabelli C, Saravolatz L, Latchman D, Knight R, Gardin J. Scarabelli TM, et al. J Am Coll Cardiol. 2004 Mar 3;43(5):865-74. doi: 10.1016/j.jacc.2003.09.050. J Am Coll Cardiol. 2004. PMID: 14998631 Free article.
Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells.
Scarabelli TM, Pasini E, Ferrari G, Ferrari M, Stephanou A, Lawrence K, Townsend P, Chen-Scarabelli C, Gitti G, Saravolatz L, Latchman D, Knight RA, Gardin JM. Scarabelli TM, et al. J Thorac Cardiovasc Surg. 2004 Sep;128(3):364-71. doi: 10.1016/j.jtcvs.2003.11.028. J Thorac Cardiovasc Surg. 2004. PMID: 15354093 Free article.
Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.
Scarabelli TM, Townsend PA, Chen Scarabelli C, Yuan Z, McCauley RB, Di Rezze J, Patel D, Putt J, Allebban Z, Abboud J, Chilukuri K, Gardin J, Saravolatz L, Knight RA, Latchman DS, Stephanou A. Scarabelli TM, et al. Am J Cardiol. 2008 Jun 2;101(11A):63E-68E. doi: 10.1016/j.amjcard.2008.03.003. Am J Cardiol. 2008. PMID: 18514629
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury.
Scarabelli TM, Mariotto S, Abdel-Azeim S, Shoji K, Darra E, Stephanou A, Chen-Scarabelli C, Marechal JD, Knight R, Ciampa A, Saravolatz L, de Prati AC, Yuan Z, Cavalieri E, Menegazzi M, Latchman D, Pizza C, Perahia D, Suzuki H. Scarabelli TM, et al. FEBS Lett. 2009 Feb 4;583(3):531-41. doi: 10.1016/j.febslet.2008.12.037. Epub 2008 Dec 29. FEBS Lett. 2009. PMID: 19116149 Free article.
Warm-blood cardioplegic arrest induces selective mitochondrial translocation of protein kinase Cepsilon followed by interaction with 6.1 inwardly rectifying potassium channel subunit in viable myocytes overexpressing urocortin.
Chen-Scarabelli C, Faggian G, Yuan Z, Tessari M, Rungatscher A, Di Rezze J, Scarabelli GM, Abounit K, McCauley R, Saravolatz L, Mazzucco A, Scarabelli TM. Chen-Scarabelli C, et al. J Thorac Cardiovasc Surg. 2009 Nov;138(5):1213-21. doi: 10.1016/j.jtcvs.2009.03.041. Epub 2009 Jun 23. J Thorac Cardiovasc Surg. 2009. PMID: 19660384 Free article.
The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications.
Ulgen BO, Field MG, Qureshi W, Knight RA, Stephanou A, Latchman DS, Vasquez D, Barry SP, Saravolatz L 2nd, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Chen-Scarabelli C, Scarabelli TM. Ulgen BO, et al. Recent Pat Cardiovasc Drug Discov. 2011 May;6(2):123-32. doi: 10.2174/157489011795933783. Recent Pat Cardiovasc Drug Discov. 2011. PMID: 21599619 Review.
188 results