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Page 1
Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection.
Yuan Z, McCauley R, Chen-Scarabelli C, Abounit K, Stephanou A, Barry SP, Knight R, Saravolatz SF, Saravolatz LD, Ulgen BO, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Scarabelli TM. Yuan Z, et al. Among authors: stephanou a. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):1-7. doi: 10.1016/j.mce.2010.04.013. Epub 2010 Apr 21. Mol Cell Endocrinol. 2010. PMID: 20416357
New targets of urocortin-mediated cardioprotection.
Barry SP, Lawrence KM, McCormick J, Soond SM, Hubank M, Eaton S, Sivarajah A, Scarabelli TM, Knight RA, Thiemermann C, Latchman DS, Townsend PA, Stephanou A. Barry SP, et al. Among authors: stephanou a. J Mol Endocrinol. 2010 Aug;45(2):69-85. doi: 10.1677/JME-09-0148. Epub 2010 May 25. J Mol Endocrinol. 2010. PMID: 20501665 Free PMC article.
The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway.
Chen-Scarabelli C, Saravolatz Ii L, McCaukey R, Scarabelli G, Di Rezze J, Mohanty B, Barry S, Latchman D, Georgiadis V, McCormick J, Saravolatz L, Knight R, Faggian G, Narula J, Stephanou A, Scarabelli TM. Chen-Scarabelli C, et al. Among authors: stephanou a. JAKSTAT. 2013 Jul 1;2(3):e24812. doi: 10.4161/jkst.24812. Epub 2013 May 7. JAKSTAT. 2013. PMID: 24069562 Free PMC article.
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO.
Scarabelli TM, Stephanou A, Pasini E, Gitti G, Townsend P, Lawrence K, Chen-Scarabelli C, Saravolatz L, Latchman D, Knight R, Gardin J. Scarabelli TM, et al. Among authors: stephanou a. J Am Coll Cardiol. 2004 Mar 3;43(5):865-74. doi: 10.1016/j.jacc.2003.09.050. J Am Coll Cardiol. 2004. PMID: 14998631 Free article.
Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells.
Scarabelli TM, Pasini E, Ferrari G, Ferrari M, Stephanou A, Lawrence K, Townsend P, Chen-Scarabelli C, Gitti G, Saravolatz L, Latchman D, Knight RA, Gardin JM. Scarabelli TM, et al. Among authors: stephanou a. J Thorac Cardiovasc Surg. 2004 Sep;128(3):364-71. doi: 10.1016/j.jtcvs.2003.11.028. J Thorac Cardiovasc Surg. 2004. PMID: 15354093 Free article.
Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.
Scarabelli TM, Townsend PA, Chen Scarabelli C, Yuan Z, McCauley RB, Di Rezze J, Patel D, Putt J, Allebban Z, Abboud J, Chilukuri K, Gardin J, Saravolatz L, Knight RA, Latchman DS, Stephanou A. Scarabelli TM, et al. Among authors: stephanou a. Am J Cardiol. 2008 Jun 2;101(11A):63E-68E. doi: 10.1016/j.amjcard.2008.03.003. Am J Cardiol. 2008. PMID: 18514629
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury.
Scarabelli TM, Mariotto S, Abdel-Azeim S, Shoji K, Darra E, Stephanou A, Chen-Scarabelli C, Marechal JD, Knight R, Ciampa A, Saravolatz L, de Prati AC, Yuan Z, Cavalieri E, Menegazzi M, Latchman D, Pizza C, Perahia D, Suzuki H. Scarabelli TM, et al. Among authors: stephanou a. FEBS Lett. 2009 Feb 4;583(3):531-41. doi: 10.1016/j.febslet.2008.12.037. Epub 2008 Dec 29. FEBS Lett. 2009. PMID: 19116149 Free article.
The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications.
Ulgen BO, Field MG, Qureshi W, Knight RA, Stephanou A, Latchman DS, Vasquez D, Barry SP, Saravolatz L 2nd, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Chen-Scarabelli C, Scarabelli TM. Ulgen BO, et al. Among authors: stephanou a. Recent Pat Cardiovasc Drug Discov. 2011 May;6(2):123-32. doi: 10.2174/157489011795933783. Recent Pat Cardiovasc Drug Discov. 2011. PMID: 21599619 Review.
182 results