Byl JA - Search Results

1

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Hawtin RE, et al. Among authors: byl ja. PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186. PLoS One. 2010. PMID: 20419121 Free PMC article.

2

A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.

Sabourin M, Byl JA, Hannah SE, Nitiss JL, Osheroff N. Sabourin M, et al. Among authors: byl ja. J Biol Chem. 1998 Oct 30;273(44):29086-92. doi: 10.1074/jbc.273.44.29086. J Biol Chem. 1998. PMID: 9786915 Free article.

3

DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement.

Byl JA, Fortune JM, Burden DA, Nitiss JL, Utsugi T, Yamada Y, Osheroff N. Byl JA, et al. Biochemistry. 1999 Nov 23;38(47):15573-9. doi: 10.1021/bi991791o. Biochemistry. 1999. PMID: 10569941

4

DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.

Byl JA, Cline SD, Utsugi T, Kobunai T, Yamada Y, Osheroff N. Byl JA, et al. Biochemistry. 2001 Jan 23;40(3):712-8. doi: 10.1021/bi0021838. Biochemistry. 2001. PMID: 11170388

5

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.

Mays AN, Osheroff N, Xiao Y, Wiemels JL, Felix CA, Byl JA, Saravanamuttu K, Peniket A, Corser R, Chang C, Hoyle C, Parker AN, Hasan SK, Lo-Coco F, Solomon E, Grimwade D. Mays AN, et al. Among authors: byl ja. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2. Blood. 2010. PMID: 19884644 Free PMC article.

6

First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA.

Turel I, Kljun J, Perdih F, Morozova E, Bakulev V, Kasyanenko N, Byl JA, Osheroff N. Turel I, et al. Among authors: byl ja. Inorg Chem. 2010 Dec 6;49(23):10750-2. doi: 10.1021/ic101355d. Epub 2010 Oct 26. Inorg Chem. 2010. PMID: 20973588 Free PMC article.

7

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.

Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S. Lee S, et al. Among authors: byl ja. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2925-30. doi: 10.1073/pnas.1115704109. Epub 2012 Feb 9. Proc Natl Acad Sci U S A. 2012. PMID: 22323612 Free PMC article.

8

Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.

Timmel MA, Byl JA, Osheroff N. Timmel MA, et al. Among authors: byl ja. Chem Res Toxicol. 2013 Apr 15;26(4):622-8. doi: 10.1021/tx4000667. Epub 2013 Apr 4. Chem Res Toxicol. 2013. PMID: 23514406 Free PMC article.

9

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.

Furniss KL, Tsai HJ, Byl JA, Lane AB, Vas AC, Hsu WS, Osheroff N, Clarke DJ. Furniss KL, et al. Among authors: byl ja. PLoS Genet. 2013;9(10):e1003832. doi: 10.1371/journal.pgen.1003832. Epub 2013 Oct 3. PLoS Genet. 2013. PMID: 24098144 Free PMC article.

10

Etoposide quinone is a covalent poison of human topoisomerase IIβ.

Smith NA, Byl JA, Mercer SL, Deweese JE, Osheroff N. Smith NA, et al. Among authors: byl ja. Biochemistry. 2014 May 20;53(19):3229-36. doi: 10.1021/bi500421q. Epub 2014 May 2. Biochemistry. 2014. PMID: 24766193 Free PMC article.

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