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Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer.
Krop IE, Beeram M, Modi S, Jones SF, Holden SN, Yu W, Girish S, Tibbitts J, Yi JH, Sliwkowski MX, Jacobson F, Lutzker SG, Burris HA. Krop IE, et al. Among authors: jacobson f. J Clin Oncol. 2010 Jun 1;28(16):2698-704. doi: 10.1200/JCO.2009.26.2071. Epub 2010 Apr 26. J Clin Oncol. 2010. PMID: 20421541 Clinical Trial.
Statistical characterization of therapeutic protein modifications.
Tsai TH, Hao Z, Hong Q, Moore B, Stella C, Zhang JH, Chen Y, Kim M, Koulis T, Ryslik GA, Verschueren E, Jacobson F, Haskins WE, Vitek O. Tsai TH, et al. Among authors: jacobson f. Sci Rep. 2017 Aug 11;7(1):7896. doi: 10.1038/s41598-017-08333-y. Sci Rep. 2017. PMID: 28801661 Free PMC article.
Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion-reversed phase two dimensional-liquid chromatography.
Li Y, Stella C, Zheng L, Bechtel C, Gruenhagen J, Jacobson F, Medley CD. Li Y, et al. Among authors: jacobson f. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:112-118. doi: 10.1016/j.jchromb.2016.05.011. Epub 2016 May 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27212187
Protein aggregation and bioprocessing.
Cromwell ME, Hilario E, Jacobson F. Cromwell ME, et al. Among authors: jacobson f. AAPS J. 2006 Sep 15;8(3):E572-9. doi: 10.1208/aapsj080366. AAPS J. 2006. PMID: 17025275 Free PMC article. Review.
249 results