Workman P - Search Results

1

AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.

Grimshaw KM, Hunter LJ, Yap TA, Heaton SP, Walton MI, Woodhead SJ, Fazal L, Reule M, Davies TG, Seavers LC, Lock V, Lyons JF, Thompson NT, Workman P, Garrett MD. Grimshaw KM, et al. Among authors: workman p. Mol Cancer Ther. 2010 May;9(5):1100-10. doi: 10.1158/1535-7163.MCT-09-0986. Epub 2010 Apr 27. Mol Cancer Ther. 2010. PMID: 20423992 Free PMC article.

2

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.

Walton MI, Bibby MC, Double JA, Plumb JA, Workman P. Walton MI, et al. Among authors: workman p. Eur J Cancer. 1992;28A(10):1597-600. doi: 10.1016/0959-8049(92)90049-8. Eur J Cancer. 1992. PMID: 1389472

3

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

Walton MI, Sugget N, Workman P. Walton MI, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1992;22(4):643-7. doi: 10.1016/0360-3016(92)90495-4. Int J Radiat Oncol Biol Phys. 1992. PMID: 1544831

4

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.

Bailey SM, Suggett N, Walton MI, Workman P. Bailey SM, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1992;22(4):649-53. doi: 10.1016/0360-3016(92)90496-5. Int J Radiat Oncol Biol Phys. 1992. PMID: 1544832

5

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.

Walton MI, Wolf CR, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1992 Jul 22;44(2):251-9. doi: 10.1016/0006-2952(92)90007-6. Biochem Pharmacol. 1992. PMID: 1642640

6

The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.

Walton MI, Smith PJ, Workman P. Walton MI, et al. Among authors: workman p. Cancer Commun. 1991 Jul;3(7):199-206. doi: 10.3727/095535491820873164. Cancer Commun. 1991. PMID: 1714284

7

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.

Walton MI, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1990 Jun 1;39(11):1735-42. doi: 10.1016/0006-2952(90)90119-6. Biochem Pharmacol. 1990. PMID: 2344370

8

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

Workman P, Walton MI, Powis G, Schlager JJ. Workman P, et al. Br J Cancer. 1989 Nov;60(5):800-2; discussion 803. doi: 10.1038/bjc.1989.364. Br J Cancer. 1989. PMID: 2508739 Free PMC article. No abstract available.

9

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.

Walton MI, Wolf CR, Workman P. Walton MI, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):983-6. doi: 10.1016/0360-3016(89)90900-0. Int J Radiat Oncol Biol Phys. 1989. PMID: 2703406

10

Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.

Walton MI, Bleehen NM, Workman P. Walton MI, et al. Among authors: workman p. Cancer Res. 1989 May 1;49(9):2351-5. Cancer Res. 1989. PMID: 2706623

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