Northen JS - Search Results

1

Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.

Wong C, Griffin RJ, Hardcastle IR, Northen JS, Wang LZ, Golding BT. Wong C, et al. Among authors: northen js. Org Biomol Chem. 2010 May 21;8(10):2457-64. doi: 10.1039/b922717b. Epub 2010 Mar 24. Org Biomol Chem. 2010. PMID: 20448906

2

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

Hardcastle IR, Ahmed SU, Atkins H, Farnie G, Golding BT, Griffin RJ, Guyenne S, Hutton C, Källblad P, Kemp SJ, Kitching MS, Newell DR, Norbedo S, Northen JS, Reid RJ, Saravanan K, Willems HM, Lunec J. Hardcastle IR, et al. Among authors: northen js. J Med Chem. 2006 Oct 19;49(21):6209-21. doi: 10.1021/jm0601194. J Med Chem. 2006. PMID: 17034127

3

Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.

Hardcastle IR, Ahmed SU, Atkins H, Calvert AH, Curtin NJ, Farnie G, Golding BT, Griffin RJ, Guyenne S, Hutton C, Källblad P, Kemp SJ, Kitching MS, Newell DR, Norbedo S, Northen JS, Reid RJ, Saravanan K, Willems HM, Lunec J. Hardcastle IR, et al. Among authors: northen js. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1515-20. doi: 10.1016/j.bmcl.2004.12.061. Bioorg Med Chem Lett. 2005. PMID: 15713419

4

Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.

Thomas HD, Saravanan K, Wang LZ, Lin MJ, Northen JS, Barlow H, Barton M, Newell DR, Griffin RJ, Golding BT, Curtin NJ. Thomas HD, et al. Among authors: northen js. Mol Cancer Ther. 2009 Jul;8(7):1828-37. doi: 10.1158/1535-7163.MCT-08-1208. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509274

5

Nucleoside transport inhibitors: structure-activity relationships for pyrimido[5,4-d]pyrimidine derivatives that potentiate pemetrexed cytotoxicity in the presence of α1-acid glycoprotein.

Saravanan K, Barlow HC, Barton M, Calvert AH, Golding BT, Newell DR, Northen JS, Curtin NJ, Thomas HD, Griffin RJ. Saravanan K, et al. Among authors: northen js. J Med Chem. 2011 Mar 24;54(6):1847-59. doi: 10.1021/jm101493z. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366300

6

Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone.

Malik V, Zhang M, Dover LG, Northen JS, Flinn A, Perry JJ, Black GW. Malik V, et al. Among authors: northen js. Mol Biosyst. 2013 Nov;9(11):2816-22. doi: 10.1039/c3mb70303g. Mol Biosyst. 2013. PMID: 24056940

7

Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids.

Chavda S, Coumbarides GS, Dingjan M, Eames J, Flinn A, Ghilagaber S, Northen J, Yohannes Y. Chavda S, et al. Chirality. 2007 May 15;19(5):366-73. doi: 10.1002/chir.20384. Chirality. 2007. PMID: 17357119

8

Mutual kinetic separation of isotopomers of pentafluorophenyl 2-phenyl propionate using quasi-enantiomeric oxazolidinones.

Chavda S, Coumbarides GS, Dingjan M, Eames J, Flinn A, Northen J. Chavda S, et al. Chirality. 2007 May 5;19(4):313-20. doi: 10.1002/chir.20364. Chirality. 2007. PMID: 17357121

9

Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement.

Tenza K, Northen JS, O'Hagan D, Slawin AM. Tenza K, et al. Among authors: northen js. Beilstein J Org Chem. 2005 Oct 17;1(1):13. doi: 10.1186/1860-5397-1-13. Beilstein J Org Chem. 2005. PMID: 16542024 Free PMC article.

10

Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis.

Pettit GR, Tan R, Northen JS, Herald DL, Chapuis JC, Pettit RK. Pettit GR, et al. Among authors: northen js. J Nat Prod. 2004 Sep;67(9):1476-82. doi: 10.1021/np0304161. J Nat Prod. 2004. PMID: 15387645

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