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Page 1
Biochemical characterization of cholesteryl ester transfer protein inhibitors.
Ranalletta M, Bierilo KK, Chen Y, Milot D, Chen Q, Tung E, Houde C, Elowe NH, Garcia-Calvo M, Porter G, Eveland S, Frantz-Wattley B, Kavana M, Addona G, Sinclair P, Sparrow C, O'Neill EA, Koblan KS, Sitlani A, Hubbard B, Fisher TS. Ranalletta M, et al. Among authors: sitlani a. J Lipid Res. 2010 Sep;51(9):2739-52. doi: 10.1194/jlr.M007468. Epub 2010 May 10. J Lipid Res. 2010. PMID: 20458119 Free PMC article.
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
Pandit S, Wisniewski D, Santoro JC, Ha S, Ramakrishnan V, Cubbon RM, Cummings RT, Wright SD, Sparrow CP, Sitlani A, Fisher TS. Pandit S, et al. Among authors: sitlani a. J Lipid Res. 2008 Jun;49(6):1333-43. doi: 10.1194/jlr.M800049-JLR200. Epub 2008 Mar 19. J Lipid Res. 2008. PMID: 18354137 Free article.
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
Ni YG, Di Marco S, Condra JH, Peterson LB, Wang W, Wang F, Pandit S, Hammond HA, Rosa R, Cummings RT, Wood DD, Liu X, Bottomley MJ, Shen X, Cubbon RM, Wang SP, Johns DG, Volpari C, Hamuro L, Chin J, Huang L, Zhao JZ, Vitelli S, Haytko P, Wisniewski D, Mitnaul LJ, Sparrow CP, Hubbard B, Carfí A, Sitlani A. Ni YG, et al. Among authors: sitlani a. J Lipid Res. 2011 Jan;52(1):78-86. doi: 10.1194/jlr.M011445. Epub 2010 Oct 19. J Lipid Res. 2011. PMID: 20959675 Free PMC article.
Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
Strack AM, Carballo-Jane E, Wang SP, Xue J, Ping X, McNamara LA, Thankappan A, Price O, Wolff M, Wu TJ, Kawka D, Mariano M, Burton C, Chang CH, Chen J, Menke J, Luell S, Zycband EI, Tong X, Raubertas R, Sparrow CP, Hubbard B, Woods J, O'Neill G, Waters MG, Sitlani A. Strack AM, et al. Among authors: sitlani a. J Lipid Res. 2013 Jan;54(1):177-88. doi: 10.1194/jlr.M031344. Epub 2012 Oct 28. J Lipid Res. 2013. PMID: 23103473 Free PMC article.
An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.
Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A. Zhang L, et al. Among authors: sitlani a. Int J Biol Sci. 2012;8(3):310-27. doi: 10.7150/ijbs.3524. Epub 2012 Feb 9. Int J Biol Sci. 2012. PMID: 22355267 Free PMC article.
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation.
Fisher TS, Lo Surdo P, Pandit S, Mattu M, Santoro JC, Wisniewski D, Cummings RT, Calzetta A, Cubbon RM, Fischer PA, Tarachandani A, De Francesco R, Wright SD, Sparrow CP, Carfi A, Sitlani A. Fisher TS, et al. Among authors: sitlani a. J Biol Chem. 2007 Jul 13;282(28):20502-12. doi: 10.1074/jbc.M701634200. Epub 2007 May 10. J Biol Chem. 2007. PMID: 17493938 Free article.
Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry.
Lee AY, Yates NA, Ichetovkin M, Deyanova E, Southwick K, Fisher TS, Wang W, Loderstedt J, Walker N, Zhou H, Zhao X, Sparrow CP, Hubbard BK, Rader DJ, Sitlani A, Millar JS, Hendrickson RC. Lee AY, et al. Among authors: sitlani a. Clin Chem. 2012 Mar;58(3):619-27. doi: 10.1373/clinchem.2011.172429. Epub 2012 Jan 16. Clin Chem. 2012. PMID: 22249652
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfí A. Bottomley MJ, et al. Among authors: sitlani a. J Biol Chem. 2009 Jan 9;284(2):1313-23. doi: 10.1074/jbc.M808363200. Epub 2008 Nov 10. J Biol Chem. 2009. PMID: 19001363 Free article.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
Ni YG, Condra JH, Orsatti L, Shen X, Di Marco S, Pandit S, Bottomley MJ, Ruggeri L, Cummings RT, Cubbon RM, Santoro JC, Ehrhardt A, Lewis D, Fisher TS, Ha S, Njimoluh L, Wood DD, Hammond HA, Wisniewski D, Volpari C, Noto A, Lo Surdo P, Hubbard B, Carfí A, Sitlani A. Ni YG, et al. Among authors: sitlani a. J Biol Chem. 2010 Apr 23;285(17):12882-91. doi: 10.1074/jbc.M110.113035. Epub 2010 Feb 19. J Biol Chem. 2010. PMID: 20172854 Free PMC article.
28 results