Crooks PA - Search Results

1

Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.

Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Matharu J, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. doi: 10.1016/j.bmcl.2010.04.086. Epub 2010 Apr 24. Bioorg Med Chem Lett. 2010. PMID: 20466543 Free PMC article.

2

In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.

Worthen DR, Bence AK, Stables JP, Crooks PA. Worthen DR, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5012-5. doi: 10.1016/j.bmcl.2009.07.059. Epub 2009 Jul 12. Bioorg Med Chem Lett. 2009. PMID: 19632831

3

Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.

Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Bence AK, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2621-3. doi: 10.1016/s0960-894x(00)00530-8. Bioorg Med Chem Lett. 2000. PMID: 11128637

4

Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.

Zheng G, Zhang Z, Lockman PR, Geldenhuys WJ, Allen DD, Dwoskin LP, Crooks PA. Zheng G, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3208-10. doi: 10.1016/j.bmcl.2010.04.098. Epub 2010 Apr 24. Bioorg Med Chem Lett. 2010. PMID: 20462759 Free PMC article.

5

bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.

Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. Zhang Z, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5622-5. doi: 10.1016/j.bmcl.2008.08.099. Epub 2008 Aug 30. Bioorg Med Chem Lett. 2008. PMID: 18793853 Free PMC article.

6

The antiproliferative and immunotoxic effects of L-canavanine and L-canaline.

Bence AK, Worthen DR, Adams VR, Crooks PA. Bence AK, et al. Among authors: crooks pa. Anticancer Drugs. 2002 Mar;13(3):313-20. doi: 10.1097/00001813-200203000-00013. Anticancer Drugs. 2002. PMID: 11984075

7

L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines.

Worthen DR, Chien L, Tsuboi CP, Mu XY, Bartik MM, Crooks PA. Worthen DR, et al. Among authors: crooks pa. Cancer Lett. 1998 Oct 23;132(1-2):229-39. doi: 10.1016/s0304-3835(98)00233-x. Cancer Lett. 1998. PMID: 10397478

8

Structure-activity studies of L-canaline-mediated inhibition of porcine alanine aminotransferase.

Worthen DR, Ratliff DK, Rosenthal GA, Trifonov L, Crooks PA. Worthen DR, et al. Among authors: crooks pa. Chem Res Toxicol. 1996 Dec;9(8):1293-7. doi: 10.1021/tx9600199. Chem Res Toxicol. 1996. PMID: 8951231

9

An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine.

Bence AK, Worthen DR, Stables JP, Crooks PA. Bence AK, et al. Among authors: crooks pa. Pharmacol Biochem Behav. 2003 Feb;74(3):771-5. doi: 10.1016/s0091-3057(02)01079-1. Pharmacol Biochem Behav. 2003. PMID: 12543244

10

3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.

Geldenhuys WJ, Lockman PR, Nguyen TH, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD. Geldenhuys WJ, et al. Among authors: crooks pa. Bioorg Med Chem. 2005 Jul 1;13(13):4253-61. doi: 10.1016/j.bmc.2005.04.020. Bioorg Med Chem. 2005. PMID: 15878282

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