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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Yoshida T, et al. Among authors: sussan t. Nat Med. 2010 Jul;16(7):767-73. doi: 10.1038/nm.2157. Epub 2010 May 16. Nat Med. 2010. PMID: 20473305 Free PMC article.
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. Sussan TE, et al. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. doi: 10.1073/pnas.0804333106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2009. PMID: 19104057 Free PMC article.
Impaired lung homeostasis in neonatal mice exposed to cigarette smoke.
McGrath-Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, Tuder RM, Biswal S. McGrath-Morrow S, et al. Among authors: sussan t. Am J Respir Cell Mol Biol. 2008 Apr;38(4):393-400. doi: 10.1165/rcmb.2007-0104OC. Epub 2007 Nov 1. Am J Respir Cell Mol Biol. 2008. PMID: 17975176 Free PMC article.
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S. Malhotra D, et al. Among authors: sussan t. Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207. doi: 10.1164/rccm.200903-0324OC. Epub 2009 Oct 1. Am J Respir Crit Care Med. 2009. Retraction in: Am J Respir Crit Care Med. 2016 Feb 1;193(3):344. doi: 10.1164/rccm.1933retraction PMID: 19797762 Free PMC article. Retracted.
Telomere length is a determinant of emphysema susceptibility.
Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Alder JK, et al. Among authors: sussan t. Am J Respir Crit Care Med. 2011 Oct 15;184(8):904-12. doi: 10.1164/rccm.201103-0520OC. Epub 2011 Jul 14. Am J Respir Crit Care Med. 2011. PMID: 21757622 Free PMC article.
38 results