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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Yoshida T, et al. Among authors: zhang l. Nat Med. 2010 Jul;16(7):767-73. doi: 10.1038/nm.2157. Epub 2010 May 16. Nat Med. 2010. PMID: 20473305 Free PMC article.
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S. Malhotra D, et al. Among authors: zhang l. Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207. doi: 10.1164/rccm.200903-0324OC. Epub 2009 Oct 1. Am J Respir Crit Care Med. 2009. Retraction in: Am J Respir Crit Care Med. 2016 Feb 1;193(3):344. doi: 10.1164/rccm.1933retraction PMID: 19797762 Free PMC article. Retracted.
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. Polverino F, et al. Among authors: zhang l, zhang d. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC. Am J Respir Crit Care Med. 2018. PMID: 29750543 Free PMC article.
Hhip haploinsufficiency sensitizes mice to age-related emphysema.
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Lao T, et al. Among authors: zhang l. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21. Proc Natl Acad Sci U S A. 2016. PMID: 27444019 Free PMC article.
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