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Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006).
Macdonough MT, Strecker TE, Hamel E, Hall JJ, Chaplin DJ, Trawick ML, Pinney KG. Macdonough MT, et al. Among authors: strecker te. Bioorg Med Chem. 2013 Nov 1;21(21):6831-43. doi: 10.1016/j.bmc.2013.07.028. Epub 2013 Jul 23. Bioorg Med Chem. 2013. PMID: 23993969 Free PMC article.
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Hadimani MB, et al. Among authors: strecker te. J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9. J Nat Prod. 2013. PMID: 24016002 Free PMC article.
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
Winn BA, Devkota L, Kuch B, MacDonough MT, Strecker TE, Wang Y, Shi Z, Gerberich JL, Mondal D, Ramirez AJ, Hamel E, Chaplin DJ, Davis P, Mason RP, Trawick ML, Pinney KG. Winn BA, et al. Among authors: strecker te. J Nat Prod. 2020 Apr 24;83(4):937-954. doi: 10.1021/acs.jnatprod.9b00773. Epub 2020 Mar 20. J Nat Prod. 2020. PMID: 32196334 Free PMC article.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG. Kishore Kumar GD, et al. Among authors: strecker te. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. doi: 10.1016/j.bmcl.2009.12.090. Epub 2010 Jan 6. Bioorg Med Chem Lett. 2010. PMID: 20089402 Free PMC article.
34 results