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Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB. Westerberg LS, et al. Among authors: meelu p. J Exp Med. 2010 Jun 7;207(6):1145-52. doi: 10.1084/jem.20091245. Epub 2010 May 31. J Exp Med. 2010. PMID: 20513746 Free PMC article.
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Cotta-de-Almeida V, et al. Among authors: meelu p. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9. doi: 10.1073/pnas.0706881104. Epub 2007 Sep 18. Proc Natl Acad Sci U S A. 2007. PMID: 17878299 Free PMC article.