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Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging.
Messa E, Carturan S, Maffè C, Pautasso M, Bracco E, Roetto A, Messa F, Arruga F, Defilippi I, Rosso V, Zanone C, Rotolo A, Greco E, Pellegrino RM, Alberti D, Saglio G, Cilloni D. Messa E, et al. Among authors: arruga f. Haematologica. 2010 Aug;95(8):1308-16. doi: 10.3324/haematol.2009.016824. Epub 2010 Jun 9. Haematologica. 2010. PMID: 20534700 Free PMC article.
Myelodysplastic syndromes.
Cilloni D, Messa F, Carturan S, Arruga F, Defilippi I, Messa E, Gottardi E, Saglio G. Cilloni D, et al. Among authors: arruga f. Ann N Y Acad Sci. 2004 Dec;1028:400-8. doi: 10.1196/annals.1322.048. Ann N Y Acad Sci. 2004. PMID: 15650265 Review.
NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line.
Morotti A, Cilloni D, Pautasso M, Messa F, Arruga F, Defilippi I, Carturan S, Catalano R, Rosso V, Chiarenza A, Taulli R, Bracco E, Rege-Cambrin G, Gottardi E, Saglio G. Morotti A, et al. Among authors: arruga f. Am J Hematol. 2006 Dec;81(12):938-45. doi: 10.1002/ajh.20732. Am J Hematol. 2006. PMID: 16960866 Free article.
CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536.
Morotti A, Parvis G, Cilloni D, Familiari U, Pautasso M, Bosa M, Messa F, Arruga F, Defilippi I, Catalano R, Rosso V, Carturan S, Bracco E, Guerrasio A, Saglio G. Morotti A, et al. Among authors: arruga f. Leukemia. 2007 Jun;21(6):1305-6. doi: 10.1038/sj.leu.2404581. Epub 2007 Mar 22. Leukemia. 2007. PMID: 17377595 No abstract available.
57 results