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Page 1
Reduced elimination of IgG antibodies by engineering the variable region.
Igawa T, Tsunoda H, Tachibana T, Maeda A, Mimoto F, Moriyama C, Nanami M, Sekimori Y, Nabuchi Y, Aso Y, Hattori K. Igawa T, et al. Among authors: tachibana t. Protein Eng Des Sel. 2010 May;23(5):385-92. doi: 10.1093/protein/gzq009. Epub 2010 Feb 15. Protein Eng Des Sel. 2010. PMID: 20159773
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.
Kamata-Sakurai M, Narita Y, Hori Y, Nemoto T, Uchikawa R, Honda M, Hironiwa N, Taniguchi K, Shida-Kawazoe M, Metsugi S, Miyazaki T, Wada NA, Ohte Y, Shimizu S, Mikami H, Tachibana T, Ono N, Adachi K, Sakiyama T, Matsushita T, Kadono S, Komatsu SI, Sakamoto A, Horikawa S, Hirako A, Hamada K, Naoi S, Savory N, Satoh Y, Sato M, Noguchi Y, Shinozuka J, Kuroi H, Ito A, Wakabayashi T, Kamimura M, Isomura F, Tomii Y, Sawada N, Kato A, Ueda O, Nakanishi Y, Endo M, Jishage KI, Kawabe Y, Kitazawa T, Igawa T. Kamata-Sakurai M, et al. Among authors: tachibana t. Cancer Discov. 2021 Jan;11(1):158-175. doi: 10.1158/2159-8290.CD-20-0328. Epub 2020 Aug 25. Cancer Discov. 2021. PMID: 32847940
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.
Igawa T, Ishii S, Tachibana T, Maeda A, Higuchi Y, Shimaoka S, Moriyama C, Watanabe T, Takubo R, Doi Y, Wakabayashi T, Hayasaka A, Kadono S, Miyazaki T, Haraya K, Sekimori Y, Kojima T, Nabuchi Y, Aso Y, Kawabe Y, Hattori K. Igawa T, et al. Among authors: tachibana t. Nat Biotechnol. 2010 Nov;28(11):1203-7. doi: 10.1038/nbt.1691. Epub 2010 Oct 17. Nat Biotechnol. 2010. PMID: 20953198
Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.
Igawa T, Maeda A, Haraya K, Tachibana T, Iwayanagi Y, Mimoto F, Higuchi Y, Ishii S, Tamba S, Hironiwa N, Nagano K, Wakabayashi T, Tsunoda H, Hattori K. Igawa T, et al. Among authors: tachibana t. PLoS One. 2013 May 7;8(5):e63236. doi: 10.1371/journal.pone.0063236. Print 2013. PLoS One. 2013. PMID: 23667591 Free PMC article.
Antibody-based therapeutics.
Tachibana T, Kuwabara T. Tachibana T, et al. Drug Metab Pharmacokinet. 2019 Feb;34(1):1-2. doi: 10.1016/j.dmpk.2019.01.006. Drug Metab Pharmacokinet. 2019. PMID: 30771882 No abstract available.
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering.
Iwayanagi Y, Igawa T, Maeda A, Haraya K, Wada NA, Shibahara N, Ohmine K, Nambu T, Nakamura G, Mimoto F, Katada H, Ito S, Tachibana T, Jishage K, Hattori K. Iwayanagi Y, et al. Among authors: tachibana t. J Immunol. 2015 Oct 1;195(7):3198-205. doi: 10.4049/jimmunol.1401470. Epub 2015 Aug 28. J Immunol. 2015. PMID: 26320252 Free PMC article.
1,322 results