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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR. Ross J, et al. Among authors: bower cc. Toxicol Sci. 2010 Aug;116(2):452-66. doi: 10.1093/toxsci/kfq118. Epub 2010 Apr 19. Toxicol Sci. 2010. PMID: 20403969