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PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind JS, Cao Y, Li X. Hou X, et al. Among authors: cao y. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12216-21. doi: 10.1073/pnas.1004143107. Epub 2010 Jun 21. Proc Natl Acad Sci U S A. 2010. PMID: 20566880 Free PMC article.
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs.
Lu H, Xu X, Zhang M, Cao R, Bråkenhielm E, Li C, Lin H, Yao G, Sun H, Qi L, Tang M, Dai H, Zhang Y, Su R, Bi Y, Zhang Y, Cao Y. Lu H, et al. Among authors: cao r, cao y. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12140-5. doi: 10.1073/pnas.0704966104. Epub 2007 Jul 16. Proc Natl Acad Sci U S A. 2007. PMID: 17636133 Free PMC article.
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X. Zhang F, et al. Among authors: cao y. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7. doi: 10.1073/pnas.0813061106. Epub 2009 Apr 6. Proc Natl Acad Sci U S A. 2009. PMID: 19369214 Free PMC article.
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X. Tang Z, et al. Among authors: cao y. J Exp Med. 2010 Apr 12;207(4):867-80. doi: 10.1084/jem.20091704. Epub 2010 Mar 15. J Exp Med. 2010. PMID: 20231377 Free PMC article.
Proliferative and survival effects of PUMA promote angiogenesis.
Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X. Zhang F, et al. Among authors: cao y. Cell Rep. 2012 Nov 29;2(5):1272-85. doi: 10.1016/j.celrep.2012.09.023. Epub 2012 Nov 1. Cell Rep. 2012. PMID: 23122957 Free article.
Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration.
He C, Zhao C, Kumar A, Lee C, Chen M, Huang L, Wang J, Ren X, Jiang Y, Chen W, Wang B, Gao Z, Zhong Z, Huang Z, Zhang F, Huang B, Ding H, Ju R, Tang Z, Liu Y, Cao Y, Li X, Liu X. He C, et al. Among authors: cao y. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14806-11. doi: 10.1073/pnas.1404140111. Epub 2014 Sep 29. Proc Natl Acad Sci U S A. 2014. PMID: 25267616 Free PMC article.
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