Li H - Search Results

1

Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.

Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Li H, et al. Biochemistry. 2010 Aug 3;49(30):6358-64. doi: 10.1021/bi100773g. Biochemistry. 2010. PMID: 20568734 Free PMC article.

2

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. Fradinger EA, et al. Among authors: li h. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14175-80. doi: 10.1073/pnas.0807163105. Epub 2008 Sep 8. Proc Natl Acad Sci U S A. 2008. PMID: 18779585 Free PMC article.

3

Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.

Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. Li H, et al. Biochemistry. 2010 Feb 16;49(6):1259-67. doi: 10.1021/bi902075h. Biochemistry. 2010. PMID: 20050679 Free PMC article.

4

C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42.

Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. Li H, et al. J Med Chem. 2011 Dec 22;54(24):8451-60. doi: 10.1021/jm200982p. Epub 2011 Nov 28. J Med Chem. 2011. PMID: 22087474 Free PMC article.

5

Aβ(39-42) modulates Aβ oligomerization but not fibril formation.

Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. Gessel MM, et al. Among authors: li h. Biochemistry. 2012 Jan 10;51(1):108-17. doi: 10.1021/bi201520b. Epub 2011 Dec 23. Biochemistry. 2012. PMID: 22129303 Free PMC article.

6

A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

Li H, Zemel R, Lopes DH, Monien BH, Bitan G. Li H, et al. ChemMedChem. 2012 Mar 5;7(3):515-22. doi: 10.1002/cmdc.201100584. Epub 2012 Feb 3. ChemMedChem. 2012. PMID: 22307963 Free PMC article.

7

Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity.

Li H, Rahimi F, Bitan G. Li H, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):845-56. doi: 10.1021/acschemneuro.6b00154. Epub 2016 Jul 5. ACS Chem Neurosci. 2016. PMID: 27322435 Free PMC article. Review.

8

Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.

Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. Urbanc B, et al. Among authors: li h. J Mol Biol. 2011 Jul 8;410(2):316-28. doi: 10.1016/j.jmb.2011.05.021. Epub 2011 May 23. J Mol Biol. 2011. PMID: 21621545 Free PMC article.

9

Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?

Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT. Zheng X, et al. Among authors: li h. J Phys Chem B. 2016 Mar 3;120(8):1615-23. doi: 10.1021/acs.jpcb.5b08177. Epub 2015 Oct 16. J Phys Chem B. 2016. PMID: 26439281 Free PMC article.

10

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons.

Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. Solomonov I, et al. Among authors: li h. J Biol Chem. 2012 Jun 8;287(24):20555-64. doi: 10.1074/jbc.M112.344036. Epub 2012 Apr 23. J Biol Chem. 2012. PMID: 22528492 Free PMC article.

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